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Structure paper

TitleStructural Basis for Nav1.5 Opening Modulated by a Gating Modifier Toxin
Journal, issue, pagesTo Be Published
Publish dateMay 15, 2022 (structure data deposition date)
AuthorsJiang D / Catterall WA
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.4 Å
Structure data

33435

7xsu

EMDB-33435, PDB-7xsu:
Cardiac sodium channel in complex with LqhIII
Method: EM (single particle) / Resolution: 3.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-BMA:
beta-D-mannopyranose

ChemComp-6OU:
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate / phospholipid*YM

ChemComp-9Z9:
(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en / detergent*YM

Source
  • rattus norvegicus (Norway rat)
  • recombinant vesicular stomatitis indiana virus rvsv-g/gfp
  • leiurus quinquestriatus hebraeus (scorpion)
KeywordsMEMBRANE PROTEIN/TOXIN / cardiac sodium channel / MEMBRANE PROTEIN / MEMBRANE PROTEIN-TOXIN complex

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