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IF

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Structure paper

TitleStructures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z.
Journal, issue, pagesCell Discov, Vol. 8, Issue 1, Page 129, Year 2022
Publish dateDec 6, 2022
AuthorsYanan Wu / Min Zhang / Yizheng Yang / Xuyang Ding / Ping Yang / Kai Huang / Xinlin Hu / Mingjie Zhang / Xiaotian Liu / Hongjun Yu /
External linksCell Discov / PubMed:36473834 / PubMed Central
MethodsEM (single particle)
Resolution2.9 - 3.2 Å
Structure data

33422

7xs6

EMDB-33422, PDB-7xs6:
structure of a membrane-integrated glycosyltransferase with inhibitor
Method: EM (single particle) / Resolution: 2.9 Å

33423

7xs7

EMDB-33423, PDB-7xs7:
structure of a membrane-integrated glycosyltransferase
Method: EM (single particle) / Resolution: 3.2 Å

Chemicals

ChemComp-C14:
TETRADECANE

ChemComp-D12:
DODECANE

ChemComp-HP6:
HEPTANE

ChemComp-BGI:
(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name) / medication, antifungal*YM

ChemComp-0V9:
(19R,22S)-25-amino-22-hydroxy-22-oxido-16-oxo-17,21,23-trioxa-22lambda~5~-phosphapentacosan-19-yl (9Z)-hexadec-9-enoate

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsMEMBRANE PROTEIN / glycosyltransferase / TRANSFERASE

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