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Structure paper

TitleStructures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.
Journal, issue, pagesCell Res, Vol. 32, Issue 8, Page 785-788, Year 2022
Publish dateMay 16, 2022
AuthorsLi-Nan Chen / Wei-Wei Wang / Ying-Jun Dong / Dan-Dan Shen / Jia Guo / Xuefei Yu / Jiao Qin / Su-Yu Ji / Huibing Zhang / Qingya Shen / Qiaojun He / Bo Yang / Yan Zhang / Qinglin Li / Chunyou Mao /
External linksCell Res / PubMed:35578016 / PubMed Central
MethodsEM (single particle)
Resolution2.7 - 2.8 Å
Structure data

32528

7wic

EMDB-32528, PDB-7wic:
Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex
Method: EM (single particle) / Resolution: 2.8 Å

32529

7wig

EMDB-32529, PDB-7wig:
Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex
Method: EM (single particle) / Resolution: 2.7 Å

Chemicals

ChemComp-9FI:
~{N}-[(2~{R})-1-[[(1~{R},3~{S})-3-(aminomethyl)cyclohexyl]methylamino]-3-(1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide

Source
  • homo sapiens (human)
  • synthetic construct (others)
  • rattus norvegicus (Norway rat)
  • bos taurus (domestic cattle)
KeywordsSTRUCTURAL PROTEIN / somatostatin receptor / somatostatin-14 / L-054 / 264 / SSTR2 / Class A GPCR / BIOSYNTHETIC PROTEIN

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