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TitleStructural insights into the peptide selectivity and activation of human neuromedin U receptors.
Journal, issue, pagesNat Commun, Vol. 13, Issue 1, Page 2045, Year 2022
Publish dateApr 19, 2022
AuthorsChongzhao You / Yumu Zhang / Peiyu Xu / Sijie Huang / Wanchao Yin / H Eric Xu / Yi Jiang /
PubMed AbstractNeuromedin U receptors (NMURs), including NMUR1 and NMUR2, are a group of G-coupled G protein-coupled receptors (GPCRs). NMUR1 and NMUR2 play distinct, pleiotropic physiological functions in ...Neuromedin U receptors (NMURs), including NMUR1 and NMUR2, are a group of G-coupled G protein-coupled receptors (GPCRs). NMUR1 and NMUR2 play distinct, pleiotropic physiological functions in peripheral tissues and in the central nervous system (CNS), respectively, according to their distinct tissue distributions. These receptors are stimulated by two endogenous neuropeptides, neuromedin U and S (NMU and NMS) with similar binding affinities. NMURs have gathered attention as potential drug targets for obesity and inflammatory disorders. Specifically, selective agonists for NMUR2 in peripheral tissue show promising long-term anti-obesity effects with fewer CNS-related side effects. However, the mechanisms of peptide binding specificity and receptor activation remain elusive. Here, we report four cryo-electron microscopy structures of G chimera-coupled NMUR1 and NMUR2 in complexes with NMU and NMS. These structures reveal the conserved overall peptide-binding mode and the mechanism of peptide selectivity for specific NMURs, as well as the common activation mechanism of the NMUR subfamily. Together, these findings provide insights into the molecular basis of the peptide recognition and offer an opportunity for the design of the selective drugs targeting NMURs.
External linksNat Commun / PubMed:35440625 / PubMed Central
MethodsEM (single particle)
Resolution2.8 - 3.2 Å
Structure data

32313

7w53

EMDB-32313, PDB-7w53:
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex
Method: EM (single particle) / Resolution: 3.2 Å

32314

7w55

EMDB-32314, PDB-7w55:
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex
Method: EM (single particle) / Resolution: 2.8 Å

32315

7w56

EMDB-32315, PDB-7w56:
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex
Method: EM (single particle) / Resolution: 2.9 Å

32316

7w57

EMDB-32316, PDB-7w57:
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex
Method: EM (single particle) / Resolution: 3.2 Å

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Cryo-EM / GPCR / Neuromedin U / neuromedin U receptor 1 / Gq / complex / neuromedin U receptor 2 / Neuromedin S

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