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TitleCryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel.
Journal, issue, pagesNature, Vol. 527, Issue 7577, Page 198-203, Year 2015
Publish dateNov 12, 2015
AuthorsRichard K Hite / Peng Yuan / Zongli Li / Yichun Hsuing / Thomas Walz / Roderick MacKinnon /
PubMed AbstractNa(+)-activated K(+) channels are members of the Slo family of large conductance K(+) channels that are widely expressed in the brain, where their opening regulates neuronal excitability. These ...Na(+)-activated K(+) channels are members of the Slo family of large conductance K(+) channels that are widely expressed in the brain, where their opening regulates neuronal excitability. These channels fulfil a number of biological roles and have intriguing biophysical properties, including conductance levels that are ten times those of most other K(+) channels and gating sensitivity to intracellular Na(+). Here we present the structure of a complete Na(+)-activated K(+) channel, chicken Slo2.2, in the Na(+)-free state, determined by cryo-electron microscopy at a nominal resolution of 4.5 ångströms. The channel is composed of a large cytoplasmic gating ring, in which resides the Na(+)-binding site and a transmembrane domain that closely resembles voltage-gated K(+) channels. In the structure, the cytoplasmic domain adopts a closed conformation and the ion conduction pore is also closed. The structure reveals features that can explain the unusually high conductance of Slo channels and how contraction of the cytoplasmic gating ring closes the pore.
External linksNature / PubMed:26436452 / PubMed Central
MethodsEM (single particle)
Resolution4.2 - 5.2 Å
Structure data

3062

5a6e

EMDB-3062: Cryo-EM structure of the Slo2.2 Na+-activated K+ channel
PDB-5a6e: Cryo-EM structure of the Slo2.2 Na-activated K channel
Method: EM (single particle) / Resolution: 4.5 Å

3063

5a6f

EMDB-3063: Cryo-EM structure of the Slo2.2 Na+-activated K+ channel
PDB-5a6f: Cryo-EM structure of the Slo2.2 Na-activated K channel
Method: EM (single particle) / Resolution: 4.2 Å

3064

5a6g

EMDB-3064: Cryo-EM structure of the Slo2.2 Na+-activated K+ channel
PDB-5a6g: Cryo-EM structure of the Slo2.2 Na-activated K channel
Method: EM (single particle) / Resolution: 5.2 Å

Source
  • gallus gallus (chicken)
KeywordsTRANSPORT / ION CHANNEL / POTASSIUM CHANNEL

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