EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant.
ジャーナル・号・ページ	Science, Vol. 374, Issue 6573, Page 1353-1360, Year 2021
掲載日	2021年12月10日
著者	Jun Zhang / Tianshu Xiao / Yongfei Cai / Christy L Lavine / Hanqin Peng / Haisun Zhu / Krishna Anand / Pei Tong / Avneesh Gautam / Megan L Mayer / Richard M Walsh / Sophia Rits-Volloch / Duane R Wesemann / Wei Yang / Michael S Seaman / Jianming Lu / Bing Chen /
PubMed 要旨	The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain worldwide. We report the structure, ...The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain worldwide. We report the structure, function, and antigenicity of its full-length spike (S) trimer as well as those of the Gamma and Kappa variants, and compare their characteristics with the G614, Alpha, and Beta variants. Delta S can fuse membranes more efficiently at low levels of cellular receptor angiotensin converting enzyme 2 (ACE2), and its pseudotyped viruses infect target cells substantially faster than the other five variants, possibly accounting for its heightened transmissibility. Each variant shows different rearrangement of the antigenic surface of the amino-terminal domain of the S protein but only makes produces changes in the receptor binding domain (RBD), making the RBD a better target for therapeutic antibodies.
リンク	Science / PubMed:34698504 / PubMed Central
手法	EM (単粒子)
解像度	3.1 - 4.4 Å
構造データ	24981 7sbk EMDB-24981, PDB-7sbk: Closed state of pre-fusion SARS-CoV-2 Delta variant spike protein 手法: EM (単粒子) / 解像度: 3.1 Å 24982 7sbl EMDB-24982, PDB-7sbl: One RBD-up 1 of pre-fusion SARS-CoV-2 Delta variant spike protein 手法: EM (単粒子) / 解像度: 3.4 Å 24983 7sbo EMDB-24983, PDB-7sbo: One RBD-up 2 of pre-fusion SARS-CoV-2 Delta variant spike protein 手法: EM (単粒子) / 解像度: 4.3 Å 24984 7sbp EMDB-24984, PDB-7sbp: Closed state of pre-fusion SARS-CoV-2 Kappa variant spike protein 手法: EM (単粒子) / 解像度: 3.1 Å 24985 7sbq EMDB-24985, PDB-7sbq: One RBD-up 1 of pre-fusion SARS-CoV-2 Kappa variant spike protein 手法: EM (単粒子) / 解像度: 3.7 Å 24986 7sbr EMDB-24986, PDB-7sbr: One RBD-up 2 of pre-fusion SARS-CoV-2 Kappa variant spike protein 手法: EM (単粒子) / 解像度: 4.3 Å 24987 7sbs EMDB-24987, PDB-7sbs: One RBD-up 1 of pre-fusion SARS-CoV-2 Gamma variant spike protein 手法: EM (単粒子) / 解像度: 3.8 Å 24988 7sbt EMDB-24988, PDB-7sbt: One RBD-up 2 of pre-fusion SARS-CoV-2 Gamma variant spike protein 手法: EM (単粒子) / 解像度: 4.4 Å
化合物	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン
由来	severe acute respiratory syndrome coronavirus 2 (ウイルス)
キーワード	VIRAL PROTEIN