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Title | Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study. |
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Journal, issue, pages | Science, Vol. 374, Issue 6566, Page 472-478, Year 2021 |
Publish date | Oct 22, 2021 |
![]() | Kathryn M Hastie / Haoyang Li / Daniel Bedinger / Sharon L Schendel / S Moses Dennison / Kan Li / Vamseedhar Rayaprolu / Xiaoying Yu / Colin Mann / Michelle Zandonatti / Ruben Diaz Avalos / Dawid Zyla / Tierra Buck / Sean Hui / Kelly Shaffer / Chitra Hariharan / Jieyun Yin / Eduardo Olmedillas / Adrian Enriquez / Diptiben Parekh / Milite Abraha / Elizabeth Feeney / Gillian Q Horn / / Yoann Aldon / Hanif Ali / Sanja Aracic / Ronald R Cobb / Ross S Federman / Joseph M Fernandez / Jacob Glanville / Robin Green / Gevorg Grigoryan / Ana G Lujan Hernandez / David D Ho / Kuan-Ying A Huang / John Ingraham / Weidong Jiang / Paul Kellam / Cheolmin Kim / Minsoo Kim / Hyeong Mi Kim / Chao Kong / Shelly J Krebs / Fei Lan / Guojun Lang / Sooyoung Lee / Cheuk Lun Leung / Junli Liu / Yanan Lu / Anna MacCamy / Andrew T McGuire / Anne L Palser / Terence H Rabbitts / Zahra Rikhtegaran Tehrani / Mohammad M Sajadi / Rogier W Sanders / Aaron K Sato / Liang Schweizer / Jimin Seo / Bingqing Shen / Jonne L Snitselaar / Leonidas Stamatatos / Yongcong Tan / Milan T Tomic / Marit J van Gils / Sawsan Youssef / Jian Yu / Tom Z Yuan / Qian Zhang / Bjoern Peters / Georgia D Tomaras / Timothy Germann / Erica Ollmann Saphire / ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
PubMed Abstract | Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in ...Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in SARS-CoV-2 that could impair antibody defenses propagated in human-to-human transmission and spillover or spillback events between humans and animals. To develop prevention and therapeutic strategies, we formed an international consortium to map the epitope landscape on the SARS-CoV-2 spike protein, defining and structurally illustrating seven receptor binding domain (RBD)–directed antibody communities with distinct footprints and competition profiles. Pseudovirion-based neutralization assays reveal spike mutations, individually and clustered together in variants, that affect antibody function among the communities. Key classes of RBD-targeted antibodies maintain neutralization activity against these emerging SARS-CoV-2 variants. These results provide a framework for selecting antibody treatment cocktails and understanding how viral variants might affect antibody therapeutic efficacy. |
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Methods | EM (single particle) |
Resolution | 9.0 - 21.0 Å |
Structure data | ![]() EMDB-24293: ![]() EMDB-24335: ![]() EMDB-24336: ![]() EMDB-24337: ![]() EMDB-24338: ![]() EMDB-24339: ![]() EMDB-24340: ![]() EMDB-24341: ![]() EMDB-24342: ![]() EMDB-24343: ![]() EMDB-24344: ![]() EMDB-24345: ![]() EMDB-24346: ![]() EMDB-24348: ![]() EMDB-24349: ![]() EMDB-24350: ![]() EMDB-24351: ![]() EMDB-24352: ![]() EMDB-24353: ![]() EMDB-24354: ![]() EMDB-24355: ![]() EMDB-24356: ![]() EMDB-24357: ![]() EMDB-24358: ![]() EMDB-24359: ![]() EMDB-24360: ![]() EMDB-24361: ![]() EMDB-24383: ![]() EMDB-24384: ![]() EMDB-24388: |
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