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Structure paper

TitleThe dynamics of hinge flexibility in receptor bound immunoglobulin E revealed by electron microscopy
Journal, issue, pagesBiorxiv, Year 2023
Publish dateMar 20, 2024 (structure data deposition date)
AuthorsJensen RK / Miehe M / Gandini R / Jorgensen MH / Spillner E / Andersen GR
External linksBiorxiv / Search PubMed
MethodsEM (single particle) / X-ray diffraction
Resolution3.1 - 8.4 Å
Structure data

19895

9eq3

EMDB-19895, PDB-9eq3:
Structure of IgE HMM5 bound to FceRIa cryo-EM class 8
Method: EM (single particle) / Resolution: 6.9 Å

19896

9eq4

EMDB-19896, PDB-9eq4:
Structure of IgE HMM5 bound to FceRIa cryo-EM class 5
Method: EM (single particle) / Resolution: 8.4 Å

PDB-8r61:
Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsIMMUNE SYSTEM / adaptive immune system IgE allergy / IgE / Fc receptor / allergy / antibody

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