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TitleTGF-beta1 activating antibodies as novel immunotherapeutics for graft-versus-host disease.
Journal, issue, pagesTo Be Published
Publish dateDec 12, 2023 (structure data deposition date)
AuthorsLambert F / Felix J / Wautier S / Gaignage M / Dupre E / Marien L / Lesage M / van der Woning B / Coulie PG / Savvides SN / Lucas S
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.98 - 3.0 Å
Structure data

19110

8rew

EMDB-19110, PDB-8rew:
CryoEM structure of human GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody.
Method: EM (single particle) / Resolution: 2.98 Å

19111

8rex

EMDB-19111, PDB-8rex:
CryoEM structure of mouse GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody.
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • lama glama (llama)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / GARP / TGF-B1 / ACTIVATION / TREG / ANTIBODY

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