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TitleImmunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein.
Journal, issue, pagesNPJ Vaccines, Vol. 9, Issue 1, Page 243, Year 2024
Publish dateDec 17, 2024
AuthorsYoung Chan Kim / Yasunori Watanabe / Arlen-Celina Lücke / Xiyong Song / Raquel de Oliveira Souza / Robert Stass / Sasha R Azar / Shannan L Rossi / Carla Claser / Beate Mareike Kümmerer / Max Crispin / Thomas A Bowden / Juha T Huiskonen / Arturo Reyes-Sandoval /
PubMed AbstractVirus-like particles (VLPs) are an established vaccine platform and can be strong immunogens capable of eliciting both humoral and cellular immune responses against a range of pathogens. Here, we ...Virus-like particles (VLPs) are an established vaccine platform and can be strong immunogens capable of eliciting both humoral and cellular immune responses against a range of pathogens. Here, we show by cryo-electron microscopy that VLPs of Mayaro virus, which contain envelope glycoproteins E1-E2 and capsid, exhibit an architecture that closely resembles native virus. In contrast to monomeric and soluble envelope 2 (E2) glycoprotein, both VLPs as well as the adenovirus and modified vaccinia virus Ankara (MVA) vaccine platforms expressing the equivalent envelope glycoproteins E1-E2, and capsid induced highly neutralising antibodies after immunisation. The levels of neutralising antibodies elicited by the viral-vectored vaccines of structural proteins and VLPs increased significantly upon boosting. Immunisation of Mayaro virus VLPs in mice with or without an adjuvant (poly:IC) yielded similar levels of neutralising antibodies suggesting that the VLPs may be used for immunisation without the need for an adjuvant. A single or two doses of non-adjuvanted 5 µg of MAYV VLP vaccination provided significant protection against viremia and MAYV-induced foot swelling in the C57BL/6 mouse challenge model. MAYV VLPs represent a non-infectious vaccine candidate, which may constitute a complementary option for future immunisation strategies against this important emerging alphavirus.
External linksNPJ Vaccines / PubMed:39690153 / PubMed Central
MethodsEM (single particle)
Resolution4.5 Å
Structure data

EMDB-15898: Recombinant Mayaro virus-like particle
Method: EM (single particle) / Resolution: 4.5 Å

Source
  • Mayaro virus

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