+検索条件
-Structure paper
タイトル | Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic. |
---|---|
ジャーナル・号・ページ | J. Med. Chem., Vol. 67, Page 3935-3958, Year 2024 |
掲載日 | 2023年10月23日 (構造データの登録日) |
![]() | Shurtleff, V.W. / Layton, M.E. / Parish, C.A. / Perkins, J.J. / Schreier, J.D. / Wang, Y. / Adam, G.C. / Alvarez, N. / Bahmanjah, S. / Bahnck-Teets, C.M. ...Shurtleff, V.W. / Layton, M.E. / Parish, C.A. / Perkins, J.J. / Schreier, J.D. / Wang, Y. / Adam, G.C. / Alvarez, N. / Bahmanjah, S. / Bahnck-Teets, C.M. / Boyce, C.W. / Burlein, C. / Cabalu, T.D. / Campbell, B.T. / Carroll, S.S. / Chang, W. / de Lera Ruiz, M. / Dolgov, E. / Fay, J.F. / Fox, N.G. / Goh, S.L. / Hartingh, T.J. / Hurzy, D.M. / Kelly 3rd, M.J. / Klein, D.J. / Klingler, F.M. / Krishnamurthy, H. / Kudalkar, S. / Mayhood, T.W. / McKenna, P.M. / Murray, E.M. / Nahas, D. / Nawrat, C.C. / Park, S. / Qian, D. / Roecker, A.J. / Sharma, V. / Shipe, W.D. / Su, J. / Taggart, R.V. / Truong, Q. / Wu, Y. / Zhou, X. / Zhuang, N. / Perlin, D.S. / Olsen, D.B. / Howe, J.A. / McCauley, J.A. |
![]() | ![]() ![]() |
手法 | X線回折 |
解像度 | 1.44 - 2.44 Å |
構造データ | ![]() PDB-8ups: ![]() PDB-8upv: ![]() PDB-8upw: ![]() PDB-8ute: |
化合物 | ![]() ChemComp-I70: ![]() ChemComp-PO4: ![]() ChemComp-HOH: ![]()
ChemComp-X83: ![]()
ChemComp-X8F: ![]()
ChemComp-XKQ: ![]() ChemComp-EDO: |
由来 |
|
![]() | VIRAL PROTEIN / HYDROLASE/INHIBITOR / 3CL Pro / MPro / inhibitor / HYDROLASE-INHIBITOR complex |