EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
ジャーナル・号・ページ	Nat Commun, Vol. 16, Page 3156-3156, Year 2025
掲載日	2022年11月15日 (構造データの登録日)
著者	Waterbury, A.L. / Caroli, J. / Zhang, O. / Tuttle, P.R. / Liu, C. / Li, J. / Park, J.S. / Hoenig, S.M. / Barone, M. / Furui, A. ...Waterbury, A.L. / Caroli, J. / Zhang, O. / Tuttle, P.R. / Liu, C. / Li, J. / Park, J.S. / Hoenig, S.M. / Barone, M. / Furui, A. / Mattevi, A. / Liau, B.B.
リンク	Nat Commun / PubMed:40175327
手法	X線回折
解像度	2.72 - 3.41 Å
構造データ	PDB-8bop: LSD1-CoREST in complex with AW4, long soaking 手法: X-RAY DIFFRACTION / 解像度: 2.74 Å PDB-8box: LSD1-CoREST in complex with AW4 and SNAG peptide 手法: X-RAY DIFFRACTION / 解像度: 2.82 Å PDB-8f2z: LSD1-CoREST in complex with AW2, short soaking 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-8f30: LSD1-CoREST in complex with AW2, long soaking 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-8f59: LSD1-CoREST in complex with AW2 and SNAG peptide 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-8f6s: LSD1-CoREST in complex with T105 手法: X-RAY DIFFRACTION / 解像度: 2.91 Å PDB-8fdv: LSD1-CoREST in complex N-formyl FAD and SNAG peptide 手法: X-RAY DIFFRACTION / 解像度: 2.95 Å PDB-8fj4: LSD1-CoREST in complex with T108, short soaking 手法: X-RAY DIFFRACTION / 解像度: 2.76 Å PDB-8fj7: LSD1-CoREST in complex with T108 and SNAG peptide 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-8fqj: LSD1-CoREST in complex with T14, short soaking 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-8fri: LSD1-CoREST in complex with AW4, short soaking 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-8frq: LSD1-CoREST in complex with T14, long soaking 手法: X-RAY DIFFRACTION / 解像度: 2.89 Å PDB-8frv: LSD1-CoREST in complex with T17, short soaking 手法: X-RAY DIFFRACTION / 解像度: 2.72 Å PDB-8fsk: LSD1-CoREST in complex with T18, short soaking 手法: X-RAY DIFFRACTION / 解像度: 3.13 Å PDB-8gj6: LSD1-CoREST in complex with T16 手法: X-RAY DIFFRACTION / 解像度: 2.77 Å PDB-8ul6: LSD1-CoREST in complex with T16, long soaking 手法: X-RAY DIFFRACTION / 解像度: 2.74 Å PDB-8ul8: LSD1-CoREST in complex with T15, short soaking 手法: X-RAY DIFFRACTION / 解像度: 2.82 Å PDB-8ulb: LSD1-CoREST in complex with T17, long soaking 手法: X-RAY DIFFRACTION / 解像度: 3.41 Å PDB-8ulc: LSD1-CoREST in complex with T15, long soaking 手法: X-RAY DIFFRACTION / 解像度: 2.82 Å PDB-8ulz: LSD1-CoREST in complex with T18 and SNAG peptide 手法: X-RAY DIFFRACTION / 解像度: 3.32 Å PDB-8umq: LSD1-CoREST in complex with T18, long soaking 手法: X-RAY DIFFRACTION / 解像度: 3.26 Å PDB-8uni: LSD1-CoREST with N-formyl-FAD in complex with H3K4M histone tail 手法: X-RAY DIFFRACTION / 解像度: 3.4 Å PDB-8uom: LSD1-CoREST with N-formyl-FAD in complex with H3dimeK4 histone tail 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-9el7: LSD1-CoREST in complex with T105 enantiomer (1R,2S) 手法: X-RAY DIFFRACTION / 解像度: 2.87 Å PDB-9el8: LSD1-CoREST in complex with T105 1S2R enantiomer 手法: X-RAY DIFFRACTION / 解像度: 2.91 Å PDB-9ela: LSD1-CoREST in complex with T108, long soaking 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å
化合物	化合物画像なし ChemComp-SV9: Unknown entry 化合物画像なし ChemComp-XB3: Unknown entry 化合物画像なし ChemComp-XB6: Unknown entry 化合物画像なし ChemComp-XHT: Unknown entry 化合物画像なし ChemComp-XHX: Unknown entry ChemComp-HUF: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-methanoyl-7,8-dimethyl-2,4-bis(oxidanylidene)-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate 化合物画像なし ChemComp-XZU: Unknown entry 化合物画像なし ChemComp-XZQ: Unknown entry 化合物画像なし ChemComp-Y0Z: Unknown entry 化合物画像なし ChemComp-Y66: Unknown entry 化合物画像なし ChemComp-Y9K: Unknown entry 化合物画像なし ChemComp-XF6: Unknown entry 化合物画像なし ChemComp-YAF: Unknown entry 化合物画像なし ChemComp-YAO: Unknown entry 化合物画像なし ChemComp-ZSI: Unknown entry ChemComp-K: Unknown entry 化合物画像なし ChemComp-XRK: Unknown entry PDB-1bi4: CATALYTIC DOMAIN OF HIV-1 INTEGRASE
由来	homo sapiens (ヒト)
キーワード	OXIDOREDUCTASE / demethylase / histone / splicing / epigenetics / Histone demethylase / Drug resistance / Covalent inhibitor / OXIDOREDUCTASE/INHIBITOR / OXIDOREDUCTASE-INHIBITOR complex