タイトル | Snapshots of the Reaction Coordinate of a Thermophilic 2'-Deoxyribonucleoside/ribonucleoside Transferase. |
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ジャーナル・号・ページ | Acs Catalysis, Vol. 14, Page 3090-3102, Year 2024 |
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掲載日 | 2023年7月11日 (構造データの登録日) |
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著者 | Tang, P. / Harding, C.J. / Dickson, A.L. / da Silva, R.G. / Harrison, D.J. / Czekster, C.M. |
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リンク | Acs Catalysis / PubMed:38449528 |
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手法 | X線回折 |
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解像度 | 1.586 - 2.23 Å |
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構造データ | PDB-8pqp: Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 D62N Mutant bound to ImmH-Forodesine 手法: X-RAY DIFFRACTION / 解像度: 1.709 Å PDB-8pqq: Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 E88Q Mutant bound to Clofarabine 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å PDB-8pqr: Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 WT bound to DAD_Immucillin-H 手法: X-RAY DIFFRACTION / 解像度: 1.586 Å PDB-8pqs: Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 E88A Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-8pqt: Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 WT bound to Bis-Tris 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-8qc0: Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 WT ribosylated 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-8rh3: Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 WT bound to Gemcitabine 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å |
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化合物 | ChemComp-IMH: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL / インムシリンH / 阻害剤*YM
ChemComp-CFB: 2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE / クロファラビン
ChemComp-DIH: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
ChemComp-BTB: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / ビストリス / pH緩衝剤*YM
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由来 | - chroococcidiopsis thermalis pcc 7203 (バクテリア)
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キーワード | PROTEIN BINDING / Complex / Transferase / ImmH-Forodesine / Mutant / Clofarabine / DAD_Immucillin-H / Bis-Tris / WT / Ribosylated / holoprotein / Gemcitabine |
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