タイトル | The catalytic mechanism of the RNA methyltransferase METTL3. |
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ジャーナル・号・ページ | Elife, Vol. 12, Year 2024 |
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掲載日 | 2023年7月19日 (構造データの登録日) |
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著者 | Corbeski, I. / Vargas-Rosales, P.A. / Bedi, R.K. / Deng, J. / Coelho, D. / Braud, E. / Iannazzo, L. / Li, Y. / Huang, D. / Etheve-Quelquejeu, M. ...Corbeski, I. / Vargas-Rosales, P.A. / Bedi, R.K. / Deng, J. / Coelho, D. / Braud, E. / Iannazzo, L. / Li, Y. / Huang, D. / Etheve-Quelquejeu, M. / Cui, Q. / Caflisch, A. |
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リンク | Elife / PubMed:38470714 |
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手法 | X線回折 |
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解像度 | 2.1 - 2.5 Å |
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構造データ | PDB-8pw8: Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA2) 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-8pw9: Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA1) 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-8pwa: Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA4) 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-8pwb: Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA6) 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-HZ2: (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid
ChemComp-H9D: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[2-[[9-[(2~{R},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethylamino]methyl]oxolane-3,4-diol
ChemComp-I0C: (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7~{H}-purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid
ChemComp-H3I: (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(7~{H}-purin-6-ylcarbamoyl)amino]-2-azanyl-butanoic acid
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE / METTL3 / bisubstrate / complex / m6A |
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