EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
ジャーナル・号・ページ	J. Med. Chem., Vol. 67, Page 8988-9027, Year 2024
掲載日	2023年7月3日 (構造データの登録日)
著者	Thomson, C. / Barton, P. / Braybrooke, E. / Colclough, N. / Dong, Z. / Evans, L. / Floc'h, N. / Guerot, C. / Hargreaves, D. / Khurana, P. ...Thomson, C. / Barton, P. / Braybrooke, E. / Colclough, N. / Dong, Z. / Evans, L. / Floc'h, N. / Guerot, C. / Hargreaves, D. / Khurana, P. / Li, S. / Li, X. / Lister, A. / McCoull, W. / McWilliams, L. / Orme, J.P. / Packer, M.J. / Swaih, A.M. / Ward, R.A. / Winlow, P. / Ye, Y.
リンク	J. Med. Chem. / PubMed:38770784
手法	X線回折
解像度	1.621 - 2.523 Å
構造データ	PDB-8pnz: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 16 bound to EGFR 手法: X-RAY DIFFRACTION / 解像度: 2.51 Å PDB-8po0: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 12 bound to EGFRinsNPG 手法: X-RAY DIFFRACTION / 解像度: 2.523 Å PDB-8po1: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 22 bound to EGFRinsNPG [V948R] 手法: X-RAY DIFFRACTION / 解像度: 2.11 Å PDB-8po2: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFRinsNPG [V948R] 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-8po3: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 18 bound to EGFR[V948R] 手法: X-RAY DIFFRACTION / 解像度: 2.13 Å PDB-8po4: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFR[V948R] 手法: X-RAY DIFFRACTION / 解像度: 1.621 Å
化合物	化合物画像なし ChemComp-2I0: Unknown entry ChemComp-HOH: WATER 化合物画像なし ChemComp-2I6: Unknown entry 化合物画像なし ChemComp-2EI: Unknown entry ChemComp-IOD: IODIDE ION / ヨ-ジド化合物画像なし ChemComp-26X: Unknown entry 化合物画像なし ChemComp-2II: Unknown entry ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP / ATP, エネルギー貯蔵分子YM ChemComp-MG*: Unknown entry / マグネシウムジカチオン
由来	homo sapiens (ヒト)
キーワード	SIGNALING PROTEIN / EGFR / Exon 20 insertion / non-small cell lung cancer / oncology