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-Structure paper
タイトル | Cryo-EM structure of severe fever with thrombocytopenia syndrome virus. |
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ジャーナル・号・ページ | Nat Commun, Vol. 14, Issue 1, Page 6333, Year 2023 |
掲載日 | 2023年10月10日 |
著者 | Shouwen Du / Ruchao Peng / Wang Xu / Xiaoyun Qu / Yuhang Wang / Jiamin Wang / Letian Li / Mingyao Tian / Yudong Guan / Jigang Wang / Guoqing Wang / Hao Li / Lingcong Deng / Xiaoshuang Shi / Yidan Ma / Fengting Liu / Minhua Sun / Zhengkai Wei / Ningyi Jin / Wei Liu / Jianxun Qi / Quan Liu / Ming Liao / Chang Li / |
PubMed 要旨 | The severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne human-infecting bunyavirus, which utilizes two envelope glycoproteins, Gn and Gc, to enter host cells. However, the ...The severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne human-infecting bunyavirus, which utilizes two envelope glycoproteins, Gn and Gc, to enter host cells. However, the structure and organization of these glycoproteins on virion surface are not yet known. Here we describe the structure of SFTSV determined by single particle reconstruction, which allows mechanistic insights into bunyavirus assembly at near-atomic resolution. The SFTSV Gn and Gc proteins exist as heterodimers and further assemble into pentameric and hexameric peplomers, shielding the Gc fusion loops by both intra- and inter-heterodimer interactions. Individual peplomers are associated mainly through the ectodomains, in which the highly conserved glycans on N914 of Gc play a crucial role. This elaborate assembly stabilizes Gc in the metastable prefusion conformation and creates some cryptic epitopes that are only accessible in the intermediate states during virus entry. These findings provide an important basis for developing vaccines and therapeutic drugs. |
リンク | Nat Commun / PubMed:37816705 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 4.3 - 6.7 Å |
構造データ | EMDB-35152: Structure of SFTSV virion EMDB-35176: 2-fold block local reconstruction of SFTSV virion EMDB-35177: 3-fold block local reconstruction of SFTSV virion EMDB-35178: 5-fold local reconstruction of SFTSV virion EMDB-35183, PDB-8i4t: EMDB-35540, PDB-8ilq: |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | VIRAL PROTEIN / SFTSV / virion / icosahedral reconstruction / VIRUS |