EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
ジャーナル・号・ページ	Nucleic Acids Res., Vol. 51, Page 4637-4649, Year 2023
掲載日	2023年1月13日 (構造データの登録日)
著者	Xiang, M. / Xia, K. / Chen, B. / Luo, Z. / Yu, Y. / Jiang, L. / Zhou, H.
リンク	Nucleic Acids Res. / PubMed:37070195
手法	X線回折
解像度	1.78 - 2.65 Å
構造データ	PDB-8i1w: The asymmetric structure of homodimeric E. coli TrpRS bound with tryptophanyl adenylate at one of its two active pockets 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-8i1y: The structure of E. coli TrpRS bound with a chemical fragment 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-8i1z: E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-8i27: E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-8i2a: E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-8i2c: E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å PDB-8i2j: E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-8i2l: E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-8i2m: The crystal structure of homodimeric E. coli tryptophanyl-tRNA synthetase bound with niraparib at one of its two active sites 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-8i4i: The asymmetric structure of homodimeric E. coli TrpRS bound with tryptophanyl adenylate and L-tryptophan 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å
化合物	ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-TYM: TRYPTOPHANYL-5'AMP ChemComp-HOH: WATER ChemComp-O7L: 5-ethanoylthiophene-2-carbonitrile / 5-アセチル-2-チオフェンカルボニトリル ChemComp-O7R: 1-(2,3-dihydro-1-benzofuran-5-yl)ethanone / 5-アセチル-2,3-ジヒドロベンゾフラン ChemComp-O8C: 4-methoxybenzenecarbonitrile / 4-メトキシベンゾニトリル ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-5OB: 5-METHOXYBENZIMIDAZOLE / 6-メトキシ-1H-ベンゾイミダゾ-ル ChemComp-O8U: 4-methoxyaniline / 4-メトキシアニリン ChemComp-O9F: 1-(4-methoxyphenyl)ethanone / 4′-メトキシアセトフェノン ChemComp-CLW: CHLORZOXAZONE / クロルゾキサゾン ChemComp-3JD: 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide / ニラパリブ / 薬剤, 抗がん剤YM ChemComp-TRP*: TRYPTOPHAN / トリプトファン
由来	escherichia coli k-12 (大腸菌)
キーワード	LIGASE / homodimer / asymmetric conformation / intermediate product / half-of-the-sites reactivity / aminoacyl-tRNA synthetase / tryptophanyl-tRNA synthetase / dimer interface / fragment screening / antibacterial / antibacterials