タイトル | Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814. |
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ジャーナル・号・ページ | Mol Biomed, Vol. 4, Page 23-23, Year 2023 |
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掲載日 | 2022年12月28日 (構造データの登録日) |
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著者 | Jiang, H. / Zou, X. / Zeng, P. / Zeng, X. / Zhou, X. / Wang, J. / Zhang, J. / Li, J. |
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リンク | Mol Biomed / PubMed:37532968 |
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手法 | X線回折 |
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解像度 | 1.7 - 2.29 Å |
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構造データ | PDB-8hvu: Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with PF07304814 手法: X-RAY DIFFRACTION / 解像度: 2.29 Å PDB-8hvv: Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF07304814 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-8hvw: Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with PF07304814 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-8hvx: Crystal structure of SARS-Cov-2 main protease Y54C mutant in complex with PF07304814 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-8hvy: Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with PF07304814 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-8hvz: Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with PF07304814 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å |
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化合物 | ChemComp-80I: [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate / 抗ウイルス剤, プロテアーゼ阻害剤*YM
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由来 | ![](img/tx_virus.gif) severe acute respiratory syndrome coronavirus 2 (ウイルス)
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キーワード | VIRAL PROTEIN/INHIBITOR / VIRAL PROTEIN-INHIBITOR COMPLEX / VIRAL PROTEIN |
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