EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
ジャーナル・号・ページ	Rsc Med Chem, Vol. 14, Page 2731-2737, Year 2023
掲載日	2022年12月26日 (構造データの登録日)
著者	Kuki, N. / Walmsley, D.L. / Kanai, K. / Takechi, S. / Yoshida, M. / Murakami, R. / Takano, K. / Tominaga, Y. / Takahashi, M. / Ito, S. ...Kuki, N. / Walmsley, D.L. / Kanai, K. / Takechi, S. / Yoshida, M. / Murakami, R. / Takano, K. / Tominaga, Y. / Takahashi, M. / Ito, S. / Nakao, N. / Angove, H. / Baker, L.M. / Carter, E. / Dokurno, P. / Le Strat, L. / Macias, A.T. / Molyneaux, C.A. / Murray, J.B. / Surgenor, A.E. / Hamada, T. / Hubbard, R.E.
リンク	Rsc Med Chem / PubMed:38107172
手法	X線回折
解像度	2.2 - 2.8 Å
構造データ	PDB-8hv1: Crystal structure of EGFR_DMX in complex with covalently bound fragment 1 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-8hv2: Crystal structure of EGFR_wt in complex with covalently bound fragment 4 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-8hv3: Crystal structure of EGFR_DMX in complex with covalently bound fragment 4 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-8hv4: Crystal structure of EGFR_TMX in complex with covalently bound fragment 4 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8hv5: Crystal structure of EGFR_DMX in complex with compound 7 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8hv6: Crystal structure of EGFR_TMX in complex with covalently bound fragment 8 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8hv7: Crystal structure of EGFR_TMX in complex with covalently bound fragment 9 手法: X-RAY DIFFRACTION / 解像度: 2.69 Å PDB-8hv8: Crystal structure of EGFR_TMX in complex with covalently bound fragment 10 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-8hv9: Crystal structure of EGFR_TMX in complex with covalently bound fragment 12 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-8hva: Crystal structure of EGFR_TMX in complex with covalently bound compound 14 手法: X-RAY DIFFRACTION / 解像度: 2.77 Å
化合物	ChemComp-PE5: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL / オクタエチレングリコ-ルモノエチルエ-テル / 沈殿剤YM ChemComp-N6N: 3-(3-bromophenyl)-1,4-dihydro-1,2,4-triazole-5-thione ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-HOH: WATER ChemComp-MWU: ~{N}-pyridin-2-ylprop-2-enamide / N-(2-ピリジル)アクリルアミド ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-CL: Unknown entry / クロリド ChemComp-N7C: ~{N}-(1-methylbenzimidazol-4-yl)prop-2-enamide ChemComp-N86: ~{N}-quinolin-7-ylprop-2-enamide ChemComp-N8O: ~{N}-[7-(dimethylamino)-2-methyl-pyrazolo[1,5-a]pyrimidin-5-yl]prop-2-enamide ChemComp-N99: ~{N}-pyrazolo[1,5-a]pyridin-2-ylprop-2-enamide ChemComp-N9L: ~{N}-(4-phenylpyridin-2-yl)prop-2-enamide ChemComp-N9R: ~{N}-[6-(1-methylindol-3-yl)pyrimidin-4-yl]prop-2-enamide
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / Epidermal growth factor receptor kinase / covalent fragments / mutant EGFR / anti-cancer