タイトル | Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC. |
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ジャーナル・号・ページ | Viruses, Vol. 15, Year 2023 |
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掲載日 | 2023年3月3日 (構造データの登録日) |
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著者 | Ding, S. / Tolbert, W.D. / Zhu, H. / Lee, D. / Marchitto, L. / Higgins, T. / Zhao, X. / Nguyen, D. / Sherburn, R. / Richard, J. ...Ding, S. / Tolbert, W.D. / Zhu, H. / Lee, D. / Marchitto, L. / Higgins, T. / Zhao, X. / Nguyen, D. / Sherburn, R. / Richard, J. / Gendron-Lepage, G. / Medjahed, H. / Mohammadi, M. / Abrams, C. / Pazgier, M. / Smith III, A.B. / Finzi, A. |
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リンク | Viruses / PubMed:37243271 |
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手法 | X線回折 |
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解像度 | 2.19 - 3.5 Å |
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構造データ | PDB-8gcz: Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with ZXC-I-090 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-8gd0: Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with TFH-I-070-A6 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-8gd1: Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with ZXC-I-092 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å PDB-8gd3: Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with DL-I-101 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-8gd5: Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with DL-I-102 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-8gjt: Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with TFH-I-116-D1 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å |
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化合物 | ChemComp-YZI: (3S,5S)-5-(aminomethyl)-N-(4-chloro-3-fluorophenyl)-1-(4-methylpiperazine-1-carbonyl)piperidine-3-carboxamide
ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
ChemComp-Z3F: (3S)-N-(4-chloro-3-fluorophenyl)-1-(4-methylpiperazine-1-carbonyl)piperidine-3-carboxamide
ChemComp-Z1I: (3S,5S)-5-(aminomethyl)-N-(4-chloro-3-fluorophenyl)-1-[(3R,5S)-3,4,5-trimethylpiperazine-1-carbonyl]piperidine-3-carboxamide
ChemComp-Z1Z: (3S,5R)-N-(4-chloro-3-fluorophenyl)-1-(4-glycylpiperazine-1-carbonyl)-5-(hydroxymethyl)piperidine-3-carboxamide
ChemComp-Z2O: {4-[(3S,5R)-3-[(4-chloro-3-fluorophenyl)carbamoyl]-5-(hydroxymethyl)piperidine-1-carbonyl]piperazin-1-yl}acetic acid
ChemComp-ZNF: (3S)-N-(4-chloro-3-fluorophenyl)-1-[(3R,5S)-3,4,5-trimethylpiperazine-1-carbonyl]piperidine-3-carboxamide
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由来 | - human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
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キーワード | VIRAL PROTEIN/INHIBITOR / HIV-1 GP120 / CLADE A/E CF01 / VIRAL PROTEIN-INHIBITOR complex |
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