EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4.
ジャーナル・号・ページ	Inorg. Chem., Vol. 62, Page 3305-3320, Year 2023
掲載日	2022年10月22日 (構造データの登録日)
著者	Denison, M. / Ahrens, J.J. / Dunbar, M.N. / Warmahaye, H. / Majeed, A. / Turro, C. / Kocarek, T.A. / Sevrioukova, I.F. / Kodanko, J.J.
リンク	Inorg. Chem. / PubMed:36758158
手法	X線回折
解像度	2.05 - 2.4 Å
構造データ	PDB-8ewd: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8ewe: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-8ewl: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-8ewm: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-8ewn: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-8ewp: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-8ewq: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-8ewr: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8ews: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-8exb: Crystal structure of CYP3A4 bound to an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å
化合物	ChemComp-HEM: PROTOPORPHYRIN IX CONTAINING FE ChemComp-WZN: {tert-butyl [1-{[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]amino}-1-oxo-3-(pyridin-4-yl)propan-2-yl]carbamate}bis[2-(quinolin-2-yl-kappaN)phenyl-kappaC~1~]iridium(1+) ChemComp-HOH: WATER ChemComp-X0E: {tert-butyl [1-{[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]amino}-1-oxo-3-(pyridin-4-yl)propan-2-yl]carbamate}bis[2-(quinolin-2-yl-kappaN)phenyl-kappaC~1~]iridium ChemComp-X1C: {N-[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]-3-(pyridin-4-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)phenyl-kappaC~1~]iridium(1+) ChemComp-X1I: {tert-butyl [1-{[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methylidene]amino}-1-oxo-3-(pyridin-4-yl)propan-2-yl]carbamate}bis[3,5-difluoro-2-(pyridin-2-yl-kappaN)phenyl-kappaC~1~]iridium(1+) ChemComp-X1O: {N-[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]-3-(pyridin-4-yl)propanamide}bis[3,5-difluoro-2-(pyridin-2-yl-kappaN)phenyl-kappaC~1~]iridium(1+) ChemComp-X2Q: {N-[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]-3-(pyridin-4-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)-1-benzothiophen-3-yl-kappaC~3~]iridium(1+) ChemComp-X2B: {N-[1-{[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]amino}-1-oxo-3-(pyridin-4-yl)propan-2-yl]benzamide}bis[2-(quinolin-2-yl-kappaN)phenyl-kappaC~1~]iridium(1+) ChemComp-X4E: {N-[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]-3-(pyridin-3-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)-1-benzothiophen-3-yl-kappaC~3~]iridium(1+)
由来	homo sapiens (ヒト)
キーワード	OXIDOREDUCTASE/INHIBITOR / cytochrome P450 / CYP3A4 / inhibitor / complex / OXIDOREDUCTASE / OXIDOREDUCTASE-INHIBITOR complex