EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
ジャーナル・号・ページ	Nat Commun, Vol. 14, Page 2259-2259, Year 2023
掲載日	2022年9月7日 (構造データの登録日)
著者	Silhan, J. / Klima, M. / Otava, T. / Skvara, P. / Chalupska, D. / Chalupsky, K. / Kozic, J. / Nencka, R. / Boura, E.
リンク	Nat Commun / PubMed:37080993
手法	X線回折
解像度	2.05 - 2.6 Å
構造データ	PDB-8b07: Crystal structure of monkeypox virus methyltransferase VP39 in complex with sinefungin 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-8ceq: Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO427 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-8cer: Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO494 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-8ces: Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO500 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-8cet: Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO507 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-8cev: Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO1119 手法: X-RAY DIFFRACTION / 解像度: 2.14 Å PDB-8cgb: Monkeypox virus VP39 in complex with SAH 手法: X-RAY DIFFRACTION / 解像度: 2.47 Å
化合物	ChemComp-SFG: SINEFUNGIN / シネフンギン ChemComp-HOH: WATER ChemComp-UF9: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-phenylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid ChemComp-UEM: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-naphthalen-1-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid ChemComp-UH2: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-[2-(1~{H}-benzimidazol-2-yl)ethynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid ChemComp-UGR: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid ChemComp-UG9: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-iodanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid ChemComp-SAH: S-ADENOSYL-L-HOMOCYSTEINE / S-アデノシルホモシステイン
由来	monkeypox virus (サル痘ウイルス)
キーワード	VIRAL PROTEIN / viral / methyltransferase / vp39 / monkeypox / capping / enzyme / mpox / inhibitor / TRANSFERASE / Ligand / Monkeypox virus