タイトル | Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agent |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2022年12月20日 (構造データの登録日) |
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著者 | Stockwell, S. / Scott, D. / Fischer, G. / Guarino Almeida, E. / Rooney, T. / Feng, J. / Moschetti, T. / Dagostin, C. / Alcaide-Lopez, A. / Rocaboy, M. ...Stockwell, S. / Scott, D. / Fischer, G. / Guarino Almeida, E. / Rooney, T. / Feng, J. / Moschetti, T. / Dagostin, C. / Alcaide-Lopez, A. / Rocaboy, M. / Srinivasan, R. / Asteian, A. / Alza, E. / Blaszczyk, B. / Wang, X. / Rossmann, M. / Perrior, T. / Blundell, T.L. / Spring, D.R. / McKenzie, G. / Abell, C. / Skidmore, J. / Venkitaraman, A. / Hyvonen, M. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.924 - 2.84 Å |
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構造データ | PDB-8c14: Aurora A kinase in complex with TPX2-inhibitor 9 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-8c1d: Aurora A kinase in complex with TPX2-inhibitor 9 手法: X-RAY DIFFRACTION / 解像度: 2.115 Å PDB-8c1e: Aurora A kinase in complex with TPX2-inhibitor 9 手法: X-RAY DIFFRACTION / 解像度: 2.798 Å PDB-8c1f: Aurora A kinase in complex with TPX2-inhibitor 6 手法: X-RAY DIFFRACTION / 解像度: 1.924 Å PDB-8c1g: Aurora A kinase in complex with TPX2-inhibitor 7 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-8c1h: Aurora A kinase in complex with TPX2-inhibitor 8 手法: X-RAY DIFFRACTION / 解像度: 2.233 Å PDB-8c1i: Aurora A kinase in complex with TPX2-inhibitor 10 手法: X-RAY DIFFRACTION / 解像度: 2.81 Å PDB-8c1k: Aurora A kinase in complex with TPX2-inhibitor CAM2602 手法: X-RAY DIFFRACTION / 解像度: 2.43 Å PDB-8c1m: Aurora A kinase in complex with TPX2-inhibitor 2 手法: X-RAY DIFFRACTION / 解像度: 2.84 Å |
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化合物 | ChemComp-T0L: 4-(4-chloranyl-3-cyano-phenyl)-1~{H}-indole-6-carboxylic acid
ChemComp-T2F: 4-(4-chlorophenyl)-7-methyl-1~{H}-indole-6-carboxylic acid
ChemComp-T0X: 4-(4-chloranyl-3-cyano-phenyl)-7-methyl-1~{H}-indole-6-carboxylic acid
ChemComp-T2O: 4-(4-chlorophenyl)-~{N}-cyclopropylsulfonyl-7-methyl-1~{H}-indole-6-carboxamide
ChemComp-T3I: 4-(4-chlorophenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide
ChemComp-T3U: 4-(4-chloranyl-3-pyrazin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide
ChemComp-T1L: 4-(4-chloranyl-3-pyridin-2-yloxy-phenyl)-~{N}-cyclopropylsulfonyl-7-methyl-1~{H}-indole-6-carboxamide
ChemComp-T4O: 4-(4-chloranyl-3-pyridin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide
ChemComp-T4X: 3-oxidanyl-5-[4-(trifluoromethyloxy)phenyl]benzoic acid
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由来 | - homo sapiens (ヒト)
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キーワード | CELL CYCLE / protein-ligand complex / kinase / protein-protein interaction inhibitor |
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