タイトル | Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 67, Page 10012-10024, Year 2024 |
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掲載日 | 2022年11月10日 (構造データの登録日) |
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著者 | Miao, Y. / Virtanen, A. / Zmajkovic, J. / Hilpert, M. / Skoda, R.C. / Silvennoinen, O. / Haikarainen, T. |
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リンク | J. Med. Chem. / PubMed:38843875 |
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手法 | X線回折 |
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解像度 | 1.3 - 1.9 Å |
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構造データ | PDB-8bm2: Crystal structure of JAK2 JH1 in complex with gandotinib 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-8bpv: Crystal structure of JAK2 JH1 in complex with pacritinib 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-8bpw: Crystal structure of JAK2 JH1 in complex with lestaurtinib 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-8bx6: Crystal structure of JAK2 JH1 in complex with cerdulatinib 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-8bx9: Crystal structure of JAK2 JH1 in complex with ilginatinib 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-8bxc: Crystal structure of JAK2 JH1 in complex with itacitinib 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-8bxh: Crystal structure of JAK2 JH1 in complex with momelotinib 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å |
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化合物 | ChemComp-QQC: 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{N}-(5-methyl-1~{H}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine / LY-2784544
ChemComp-6T3: 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene / 薬剤, 抗がん剤, 阻害剤*YM
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / Janus kinase / inhibitor complex / JAK2 / JH1 |
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