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-Structure paper
タイトル | Structural basis for Fc receptor recognition of immunoglobulin M. |
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ジャーナル・号・ページ | Nat Struct Mol Biol, Vol. 30, Issue 7, Page 1033-1039, Year 2023 |
掲載日 | 2023年4月24日 |
著者 | Qu Chen / Rajesh P Menon / Laura Masino / Pavel Tolar / Peter B Rosenthal / |
PubMed 要旨 | Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune ...Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune cells, clearance of immune complexes and regulation of antibody production. FcμR is the immunoglobulin M (IgM) antibody isotype-specific Fc receptor involved in the survival and activation of B cells. Here we reveal eight binding sites for the human FcμR immunoglobulin domain on the IgM pentamer by cryogenic electron microscopy. One of the sites overlaps with the binding site for the polymeric immunoglobulin receptor (pIgR), but a different mode of FcμR binding explains its antibody isotype specificity. Variation in FcμR binding sites and their occupancy reflects the asymmetry of the IgM pentameric core and the versatility of FcμR binding. The complex explains engagement with polymeric serum IgM and the monomeric IgM B-cell receptor (BCR). |
リンク | Nat Struct Mol Biol / PubMed:37095205 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.1 - 3.63 Å |
構造データ | EMDB-16150, PDB-8bpe: EMDB-16151, PDB-8bpf: EMDB-16152, PDB-8bpg: |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | IMMUNE SYSTEM / IgM Fc receptor |