タイトル | Structural analysis of an anthrol reductase inspires enantioselective synthesis of enantiopure hydroxycycloketones and beta-halohydrins. |
---|
ジャーナル・号・ページ | Nat Commun, Vol. 14, Page 353-353, Year 2023 |
---|
掲載日 | 2022年6月28日 (構造データの登録日) |
---|
著者 | Hou, X. / Xu, H. / Yuan, Z. / Deng, Z. / Fu, K. / Gao, Y. / Liu, C. / Zhang, Y. / Rao, Y. |
---|
リンク | Nat Commun / PubMed:36681664 |
---|
手法 | X線回折 |
---|
解像度 | 1.85 - 3.3 Å |
---|
構造データ | PDB-7yb1: Crystal Structure of anthrol reductase (CbAR) in complex with NADP+ 手法: X-RAY DIFFRACTION / 解像度: 3.3 Å PDB-7yb2: Crystal Structure of anthrol reductase (CbAR) in complex with NADP+ and emodin 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-8hfj: Crystal Structure of CbAR mutant (H162F) in complex with NADP+ and a bulky 1,3-cyclodiketone 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-8hfk: Crystal Structure of CbAR mutant (H162F) in complex with NADP+ and halogenated aryl ketone 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å |
---|
化合物 | ChemComp-NAP: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
ChemComp-L7Z: 2-methyl-2-[(4-methylphenyl)methyl]cyclopentane-1,3-dione
ChemComp-L8U: 2-bromanyl-1-(4-bromanyl-2-oxidanyl-phenyl)ethanone
|
---|
由来 | cercospora sp. jnu001 (菌類)
|
---|
キーワード | OXIDOREDUCTASE / anthrol reductase / chiral alcohol / emodin |
---|