タイトル | Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain |
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ジャーナル・号・ページ | Biochem. Biophys. Res. Commun., Vol. 623, Page 17-22, Year 2022 |
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掲載日 | 2022年4月7日 (構造データの登録日) |
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著者 | Xu, H. / Luo, G. / Wu, T. / Hu, J. / Wang, C. / Wu, X. / Zhang, Y. / Xu, Y. / Xiang, Q. |
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リンク | Biochem. Biophys. Res. Commun. / PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.59 - 1.75 Å |
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構造データ | PDB-7xh6: Crystal structure of CBP bromodomain liganded with CCS1477 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-7xhe: Crystal structure of CBP bromodomain liganded with CCS151 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-7xi0: Crystal structure of CBP bromodomain liganded with CCS150 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å |
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化合物 | ChemComp-JHL: (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one
ChemComp-JHF: (6S)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(3R)-1-methylsulfonylpyrrolidin-3-yl]benzimidazol-2-yl]-1-(3-fluoranyl-4-methoxy-phenyl)piperidin-2-one
ChemComp-EL0: (6S)-1-(3-chloranyl-4-methoxy-phenyl)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(3R)-1-methylsulfonylpyrrolidin-3-yl]benzimidazol-2-yl]piperidin-2-one
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由来 | homo sapiens (ヒト)
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キーワード | PROTEIN BINDING / Histone acetyltransferase / CBP / Bromodomain |
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