タイトル | Structural Study of Metal Binding and Coordination in Ancient Metallo-beta-Lactamase PNGM-1 Variants. |
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ジャーナル・号・ページ | Int J Mol Sci, Vol. 21, Year 2020 |
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掲載日 | 2020年4月24日 (構造データの登録日) |
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著者 | Park, Y.S. / Kim, T.Y. / Park, H. / Lee, J.H. / Nguyen, D.Q. / Hong, M.K. / Lee, S.H. / Kang, L.W. |
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リンク | Int J Mol Sci / PubMed:32664695 |
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手法 | X線回折 |
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解像度 | 1.61 - 2.45 Å |
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構造データ | PDB-7byq: The mutant variant of PNGM-1. H279A was substituted for alanine to study metal coordination. 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-7bz1: The mutant variant of PNGM-1. H96 was substituted for alanine to study metal coordination. 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-7bz3: The mutant variant of PNGM-1. H257 was substituted for alanine to study substrate binding. 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7bz4: The mutant variant of PNGM-1. H279 was substituted for alanine to study metal coordination. 手法: X-RAY DIFFRACTION / 解像度: 2.16 Å PDB-7bzi: The mutant variant of PNGM-1. H91 was substituted for alanine to study metal coordination. 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-7wi1: The mutant variant of PNGM-1, H93 was substituuted for alanine to study metal coordination 手法: X-RAY DIFFRACTION / 解像度: 1.61 Å |
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化合物 | |
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由来 | uncultured bacterium (環境試料)
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キーワード | ANTIBIOTIC / RNase Z / MBLs / Zinc binding motif / carbapenemase / HYDROLASE |
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