+検索条件
-Structure paper
タイトル | Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2. |
---|---|
ジャーナル・号・ページ | Cell, Vol. 185, Issue 4, Page 630-640.e10, Year 2022 |
掲載日 | 2022年2月17日 |
![]() | Pengcheng Han / Linjie Li / Sheng Liu / Qisheng Wang / Di Zhang / Zepeng Xu / Pu Han / Xiaomei Li / Qi Peng / Chao Su / Baihan Huang / Dedong Li / Rong Zhang / Mingxiong Tian / Lutang Fu / Yuanzhu Gao / Xin Zhao / Kefang Liu / Jianxun Qi / George F Gao / Peiyi Wang / ![]() |
PubMed 要旨 | The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529), which obtains a large ...The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529), which obtains a large number of mutations in the receptor-binding domain (RBD) of the spike protein, has risen to intense scientific and public attention. Here, we studied the binding properties between the human receptor ACE2 (hACE2) and the VOC RBDs and resolved the crystal and cryoelectron microscopy structures of the omicron RBD-hACE2 complex as well as the crystal structure of the delta RBD-hACE2 complex. We found that, unlike alpha, beta, and gamma, omicron RBD binds to hACE2 at a similar affinity to that of the prototype RBD, which might be due to compensation of multiple mutations for both immune escape and transmissibility. The complex structures of omicron RBD-hACE2 and delta RBD-hACE2 reveal the structural basis of how RBD-specific mutations bind to hACE2. |
![]() | ![]() ![]() ![]() |
手法 | EM (単粒子) / X線回折 |
解像度 | 3 - 3.4 Å |
構造データ | EMDB-32405, PDB-7wbl: ![]() PDB-7wbp: ![]() PDB-7wbq: |
化合物 | ![]() ChemComp-NAG: ![]() ChemComp-ZN: |
由来 |
|
![]() | VIRAL PROTEIN / complex |