Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
PDB-6v6x: The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000988632 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å
PDB-6v9e: The crystal structure of the 2009 H1N1 PA endonuclease wild type in complex with SJ000988632 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å
PDB-6vbr: The crystal structure of the 2009 H1N1/California PA endonuclease wild type in complex with SJ000986248 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å
PDB-6vg9: The crystal structure of the 2009 H1N1/California PA endonuclease I38T mutant in complex with SJ000986248 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å
PDB-6viv: The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986192 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å
PDB-6vjh: The crystal structure of the 2009 H1N1/California PA endonuclease wild type in complex with SJ000986192 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å
PDB-6vl3: The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986436 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å
PDB-6wij: The crystal structure of the 2009/H1N1/California PA endonuclease mutant I38T in complex with SJ000986448 手法: X-RAY DIFFRACTION / 解像度: 2.44 Å
PDB-6wj4: The crystal structure of the 2009/H1N1/California PA endonuclease wild type in complex with SJ000986448 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å
PDB-7k87: The crystal structure of the 2009 H1N1 PA endonuclease in complex with SJ000986436 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å
PDB-7lm4: The crystal structure of the I38T mutant PA Endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988503 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å
PDB-7lw6: The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with Raltegravir 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å
PDB-7m0n: The crystal structure of wild type PA endonuclease (A/Vietnam/1203/2004) in complex with Raltegravir 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å
PDB-7mpf: The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000986436 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å
PDB-7mty: The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988569 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å
PDB-7n47: The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988514 手法: X-RAY DIFFRACTION / 解像度: 2.37 Å
PDB-7n55: The crystal structure of the mutant I38T PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988514 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å
PDB-7n68: The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988288 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å
PDB-7n8f: The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988288 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å
PDB-7rkp: The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with cyclic compound SJ001034733 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å
PDB-7umr: The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001034732-1 (trans-form) 手法: X-RAY DIFFRACTION / 解像度: 2.53 Å
PDB-7uuh: The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001034732-2 (cis-form) 手法: X-RAY DIFFRACTION / 解像度: 2.89 Å
PDB-8dip: The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023030 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å
PDB-8dpj: The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023030 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å
PDB-8dtw: The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023036 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å
PDB-8e4s: The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023034 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å