タイトル | Discovery of hPANK Activators with Improved Pharmacological Properties |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2022年3月21日 (構造データの登録日) |
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著者 | Tangallapally, R. / Edwards, A. / Subramanian, C. / Sharma, L.K. / Yun, M. / White, S.W. / Jackowski, S. / Rock, C.O. / Lee, R.E. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.55 - 2 Å |
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構造データ | PDB-7ue3: PANK3 complex structure with compound PZ-3804 手法: X-RAY DIFFRACTION / 解像度: 1.56 Å PDB-7ue4: PANK3 complex structure with compound PZ-3855 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-7ue5: PANK3 complex structure with compound PZ-3741 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å PDB-7ue6: PANK3 complex structure with compound PZ-3802 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-7ue7: PANK3 complex structure with compound PZ-3883 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-7ueo: PANK3 complex structure with compound PZ-3977 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7uep: PANK3 complex structure with compound PZ-3860 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7ueq: PANK3 complex structure with compound PZ-4061 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7uer: PANK3 complex structure with compound PZ-4071 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7ues: PANK3 complex structure with compound PZ-4202 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7uet: PANK3 complex structure with compound PZ-4140 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7ueu: PANK3 complex structure with compound PZ-4215 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7uev: PANK3 complex structure with compound PZ-4200 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7uex: PANK3 complex structure with compound PZ-4127 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7uey: PANK3 complex structure with compound PZ-4128 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å |
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化合物 | ChemComp-ND6: 6-[4-({4-[(2R)-1-hydroxypropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile
ChemComp-ANP: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP / AMP-PNP, エネルギー貯蔵分子類似体*YM
ChemComp-Y89: 1-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-(4-cyclopropylphenyl)ethan-1-one
ChemComp-Y88: 6-[4-({4-[(2R)-1,1,1-trifluoropropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile
ChemComp-Y99: 6-[4-({4-[(2S)-1,1,1-trifluoropropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile
ChemComp-NDK: 6-(4-{[5-fluoro-6-(propan-2-yl)pyridin-3-yl]acetyl}piperazin-1-yl)pyridazine-3-carbonitrile
ChemComp-NE3: 6-{4-[(4-cyclopropyl-3-fluorophenyl)acetyl]piperazin-1-yl}pyridazine-3-carbonitrile
ChemComp-Y90: 6-{4-[(4-cyclopropyl-2-fluorophenyl)acetyl]piperazin-1-yl}pyridazine-3-carbonitrile
ChemComp-Y93: 1-[(2R)-4-(6-chloropyridazin-3-yl)-2-methylpiperazin-1-yl]-2-(4-cyclopropylphenyl)ethan-1-one
ChemComp-N06: 1-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-[4-(dimethylamino)phenyl]ethan-1-one
ChemComp-N1F: N-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}phenyl)acetamide
ChemComp-MXO: N-(4-{2-[4-(6-cyanopyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}phenyl)methanesulfonamide
ChemComp-MXW: N-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}phenyl)methanesulfonamide
ChemComp-YX5: N-(4-{2-[4-(6-cyanopyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}phenyl)ethanesulfonamide
ChemComp-N0I: N-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}phenyl)-N-methylmethanesulfonamide
ChemComp-MZI: 2-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}anilino)-2-oxoethyl acetate
ChemComp-N0R: N-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}phenyl)-2-hydroxyacetamide
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / PANK / Substrate / Complex / Pantothenate kinase / Inhibitor / Activator / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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