タイトル | Identification of Endoplasmic Reticulum alpha-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design. |
---|
ジャーナル・号・ページ | Biochemistry, Vol. 61, Page 822-832, Year 2022 |
---|
掲載日 | 2021年12月13日 (構造データの登録日) |
---|
著者 | Karade, S.S. / Kolesnikov, A. / Treston, A.M. / Mariuzza, R.A. |
---|
リンク | Biochemistry / PubMed:35476408 |
---|
手法 | X線回折 |
---|
解像度 | 2.19 - 2.6 Å |
---|
構造データ | PDB-7t66: Co-crystal structure of Chaetomium glucosidase with compound UV-4 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-7t68: Co-crystal structure of Chaetomium glucosidase with compound UV-5 手法: X-RAY DIFFRACTION / 解像度: 2.32 Å PDB-7t6w: Crystal structure of Chaetomium Glucosidase I (apo) 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7t8v: Co-crystal structure of Chaetomium glucosidase I with EB-0159 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å |
---|
化合物 | ChemComp-BTB: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / ビストリス / pH緩衝剤*YM
ChemComp-GII: (2R,3R,4R,5S)-1-[6-(4-azido-2-nitroanilino)hexyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
ChemComp-W9Y: (1S,2S,3R,4S,5S)-1-(hydroxymethyl)-5-[(6-{[2-nitro-4-(1H-1,2,3-triazol-1-yl)phenyl]amino}hexyl)amino]cyclohexane-1,2,3,4-tetrol
|
---|
由来 | chaetomium thermophilum var. thermophilum dsm 1495 (菌類)
|
---|
キーワード | HYDROLASE/INHIBITOR / alpha glucosidase I / Hydrolase / Inhibitor complex / HYDROLASE-INHIBITOR complex / Chaetomium |
---|