タイトル | Development of PRPK Directed Phthalimides |
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ジャーナル・号・ページ | Biorxiv, Year 2021 |
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掲載日 | 2021年11月27日 (構造データの登録日) |
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著者 | Seo, H.-S. / Mizutani, T. / Hideshima, T. / Vangos, N.E. / Zhang, T. / Anderson, K.C. / Gray, N.S. / Dhe-Paganon, S. |
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リンク | Biorxiv / PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.71 - 2.05 Å |
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構造データ | PDB-7sza: Crystal Structure Analysis of human PRPK complex with a compound 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7szb: Crystal Structure Analysis of human PRPK complex with a compound 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-7szc: Crystal Structure Analysis of human PRPK complex with a compound 手法: X-RAY DIFFRACTION / 解像度: 1.71 Å PDB-7szd: Crystal Structure Analysis of human PRPK complex with a compound 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å |
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化合物 | ChemComp-DQ4: 5-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione
ChemComp-DO0: 4-hydroxy-2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione
ChemComp-DVO: 2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / protein kinase / p53 / immunomodulatory drugs / IMiDs |
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