タイトル | Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists. |
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ジャーナル・号・ページ | Cell Chem Biol, Year 2023 |
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掲載日 | 2021年10月10日 (構造データの登録日) |
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著者 | Xie, W. / Lama, L. / Yang, X. / Kuryavyi, V. / Bhattacharya, S. / Nudelman, I. / Yang, G. / Ouerfelli, O. / Glickman, J.F. / Jones, R.A. ...Xie, W. / Lama, L. / Yang, X. / Kuryavyi, V. / Bhattacharya, S. / Nudelman, I. / Yang, G. / Ouerfelli, O. / Glickman, J.F. / Jones, R.A. / Tuschl, T. / Patel, D.J. |
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リンク | Cell Chem Biol / PubMed:37536341 |
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手法 | X線回折 |
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解像度 | 2.2 - 2.25 Å |
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構造データ | PDB-7sho: Crystal structure of hSTING in complex with c[2',3'-(ara-2'-G, ribo-3'-A)-MP] (RJ242) 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-7shp: Crystal structure of hSTING in complex with c[2',3'-(ribo-2'-G, xylo-3'-A)-MP](RJ244) 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å |
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化合物 | ChemComp-9UH: (2R,5R,7R,8S,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione
ChemComp-9UR: (2S,5R,7R,8R,10S,12aR,14R,15R,15aR,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione
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由来 | homo sapiens (ヒト)
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キーワード | IMMUNE SYSTEM / STING / agonist / cGAMP analogs |
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