タイトル | Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. |
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ジャーナル・号・ページ | Eur. J. Med. Chem., Vol. 237, Page 114362-114362, Year 2022 |
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掲載日 | 2021年10月6日 (構造データの登録日) |
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著者 | Nizi, M.G. / Maksimainen, M.M. / Murthy, S. / Massari, S. / Alaviuhkola, J. / Lippok, B.E. / Sowa, S.T. / Galera-Prat, A. / Prunskaite-Hyyrylainen, R. / Luscher, B. ...Nizi, M.G. / Maksimainen, M.M. / Murthy, S. / Massari, S. / Alaviuhkola, J. / Lippok, B.E. / Sowa, S.T. / Galera-Prat, A. / Prunskaite-Hyyrylainen, R. / Luscher, B. / Korn, P. / Lehtio, L. / Tabarrini, O. |
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リンク | Eur. J. Med. Chem. / PubMed:35500474 |
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手法 | X線回折 |
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解像度 | 1.35 - 2.15 Å |
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構造データ | PDB-7pw3: PARP15 catalytic domain in complex with OUL217 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-7pwa: PARP15 catalytic domain in complex with OUL237 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-7pwc: PARP15 catalytic domain in complex with OUL238 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-7pwk: PARP15 catalytic domain in complex with OUL239 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7pwl: PARP15 catalytic domain in complex with OUL218 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-7pwm: PARP15 catalytic domain in complex with OUL252 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-7pwp: PARP15 catalytic domain in complex with OUL221 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-7pwq: PARP15 catalytic domain in complex with OUL240 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7pwr: PARP15 catalytic domain in complex with OUL254 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-7pws: PARP15 catalytic domain in complex with OUL255 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7pwu: PARP15 catalytic domain in complex with OUL256 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7pww: PARP15 catalytic domain in complex with OUL224 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-7px6: PARP15 catalytic domain in complex with OUL241 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-7px7: PARP15 catalytic domain in complex with OUL242 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å |
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化合物 | ChemComp-8AQ: 4-(cyclohexylmethoxy)-2-methoxy-benzamide
ChemComp-8BE: 4-[(3-bromophenyl)methoxy]-2-methoxy-benzamide
ChemComp-8A8: 6-(cyclohexylmethoxy)phthalazine-1,4-dione
ChemComp-89Z: 6-(cyclopentylmethoxy)phthalazine-1,4-dione
ChemComp-8BW: 6-(cyclobutylmethoxy)phthalazine-1,4-dione
ChemComp-89H: 6-(cyclopropylmethoxy)phthalazine-1,4-dione
ChemComp-8B5: 6-[(3-bromophenyl)methoxy]phthalazine-1,4-dione
ChemComp-8D2: 6-[(2-fluorophenyl)methoxy]phthalazine-1,4-dione
ChemComp-8DB: 6-(thiophen-2-ylmethoxy)phthalazine-1,4-dione
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / ADP-ribosyltransferase / Inhibitor / Complex |
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