タイトル | Peroxy Intermediate Drives Carbon Bond Activation in the Dioxygenase AsqJ. |
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ジャーナル・号・ページ | J. Am. Chem. Soc., Vol. 144, Page 15622-15632, Year 2022 |
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掲載日 | 2021年5月20日 (構造データの登録日) |
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著者 | Auman, D. / Ecker, F. / Mader, S.L. / Dorst, K.M. / Brauer, A. / Widmalm, G. / Groll, M. / Kaila, V.R.I. |
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リンク | J. Am. Chem. Soc. / PubMed:35980821 |
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手法 | X線回折 |
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解像度 | 1.5 - 2.1 Å |
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構造データ | PDB-7olk: Dioxygenase AsqJ in complex with 2b and Tris 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7oll: Dioxygenase AsqJ mutant (V72I) in complex with 2b and Tris 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7olm: Dioxygenase AsqJ mutant (V72I) in complex with 2b-O-O and Tris 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-7olo: Dioxygenase AsqJ mutant (V72I) in complex with 2b and glycerol 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7olp: Dioxygenase AsqJ mutant (V72I) in complex with 2 and alpha-ketoglutarate 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-7olq: Dioxygenase AsqJ mutant (V72I) in complex with 2 and Tris 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-7olr: Dioxygenase AsqJ in complex with 2 and alpha-ketoglutarate 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-7olt: Dioxygenase AsqJ in complex with 2 and Tris 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å |
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化合物 | ChemComp-CO0: (3~{Z})-4-methyl-3-(phenylmethylidene)-1~{H}-1,4-benzodiazepine-2,5-dione
ChemComp-VJQ: 3-[(S)-dioxidanyl(phenyl)methyl]-4-methyl-2-oxidanyl-1H-1,4-benzodiazepin-5-one
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由来 | ![](img/tx_fungus.gif) emericella nidulans (strain fgsc a4 / atcc 38163 / cbs 112.46 / nrrl 194 / m139) (カビ)
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キーワード | OXIDOREDUCTASE / Quinolone Biosynthesis / Molecular Engineering / Epoxidation / Catalytic Mechanism |
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