EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
ジャーナル・号・ページ	Proc. Natl. Acad. Sci. USA, Vol. 118, Year 2021
掲載日	2021年6月9日 (構造データの登録日)
著者	Chen, S. / Chandra Tjin, C. / Gao, X. / Xue, Y. / Jiao, H. / Zhang, R. / Wu, M. / He, Z. / Ellman, J. / Ha, Y.
リンク	Proc. Natl. Acad. Sci. USA / PubMed:34001596
手法	X線回折
解像度	2 - 2.7 Å
構造データ	PDB-7n6z: Crystal Structure of PI5P4KIIAlpha 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-7n71: Crystal Structure of PI5P4KIIAlpha 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-7n7j: Crystal Structure of PI5P4KIIAlpha complex with AMPPNP 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-7n7k: Crystal Structure of PI5P4KIIAlpha complex with AMPPNP 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7n7l: Crystal Structure of PI5P4KIIAlpha complex with BI-D1870 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-7n7m: Crystal Structure of PI5P4KIIAlpha complex with BI-2536 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7n7n: Crystal Structure of PI5P4KIIAlpha complex with Volasertib 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-7n7o: Crystal Structure of PI5P4KIIAlpha complex with Palbociclib 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-7n80: Crystal Structure of PI5P4KIIBeta 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-7n81: Crystal Structure of PI5P4KIIBeta complex with CC260 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å
化合物	ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-HOH: WATER ChemComp-MN: Unknown entry ChemComp-ANP: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP / AMP-PNP, エネルギー貯蔵分子類似体YM ChemComp-584: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one ChemComp-R78: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide / BI-2536 ChemComp-IBI: N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide / ボラセルチブ / 抗がん剤, 阻害剤YM ChemComp-LQQ: 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE / パルボシクリブ / 薬剤, 阻害剤YM ChemComp-HKP*: (7R)-8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-5-methyl-7,8-dihydropteridin-6(5H)-one
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / kinase / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex