タイトル | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 118, Year 2021 |
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掲載日 | 2021年6月9日 (構造データの登録日) |
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著者 | Chen, S. / Chandra Tjin, C. / Gao, X. / Xue, Y. / Jiao, H. / Zhang, R. / Wu, M. / He, Z. / Ellman, J. / Ha, Y. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:34001596 |
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手法 | X線回折 |
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解像度 | 2 - 2.7 Å |
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構造データ | PDB-7n6z: Crystal Structure of PI5P4KIIAlpha 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-7n71: Crystal Structure of PI5P4KIIAlpha 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-7n7j: Crystal Structure of PI5P4KIIAlpha complex with AMPPNP 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-7n7k: Crystal Structure of PI5P4KIIAlpha complex with AMPPNP 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7n7l: Crystal Structure of PI5P4KIIAlpha complex with BI-D1870 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-7n7m: Crystal Structure of PI5P4KIIAlpha complex with BI-2536 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7n7n: Crystal Structure of PI5P4KIIAlpha complex with Volasertib 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-7n7o: Crystal Structure of PI5P4KIIAlpha complex with Palbociclib 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-7n80: Crystal Structure of PI5P4KIIBeta 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-7n81: Crystal Structure of PI5P4KIIBeta complex with CC260 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å |
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化合物 | ChemComp-ANP: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP / AMP-PNP, エネルギー貯蔵分子類似体*YM
ChemComp-584: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one
ChemComp-R78: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide / BI-2536
ChemComp-IBI: N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide / ボラセルチブ / 抗がん剤, 阻害剤*YM
ChemComp-LQQ: 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE / パルボシクリブ / 薬剤, 阻害剤*YM
ChemComp-HKP: (7R)-8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-5-methyl-7,8-dihydropteridin-6(5H)-one
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / kinase / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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