タイトル | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. |
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ジャーナル・号・ページ | Science, Vol. 372, Page 1169-1175, Year 2021 |
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掲載日 | 2021年4月1日 (構造データの登録日) |
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著者 | Shatalin, K. / Nuthanakanti, A. / Kaushik, A. / Shishov, D. / Peselis, A. / Shamovsky, I. / Pani, B. / Lechpammer, M. / Vasilyev, N. / Shatalina, E. ...Shatalin, K. / Nuthanakanti, A. / Kaushik, A. / Shishov, D. / Peselis, A. / Shamovsky, I. / Pani, B. / Lechpammer, M. / Vasilyev, N. / Shatalina, E. / Rebatchouk, D. / Mironov, A. / Fedichev, P. / Serganov, A. / Nudler, E. |
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リンク | Science / PubMed:34112687 |
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手法 | X線回折 |
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解像度 | 1.6 - 2.84 Å |
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構造データ | PDB-7mcb: Crystal structure of Staphylococcus aureus Cystathionine gamma lyase Holoenzyme 手法: X-RAY DIFFRACTION / 解像度: 2.14 Å PDB-7mcl: Crystal structure of Staphylococcus aureus Cystathionine gamma-lyase, PLP bound 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-7mcn: Crystal structure of Staphylococcus aureus Cystathionine gamma-lyase, Holoenzyme with High HEPES 手法: X-RAY DIFFRACTION / 解像度: 2.52 Å PDB-7mcp: Crystal structure of Staphylococcus aureus Cystathionine gamma-lyase, Holoenzyme dimer 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-7mcq: Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, AOAA-bound enzyme in dimeric form 手法: X-RAY DIFFRACTION / 解像度: 2.84 Å PDB-7mct: Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, Holoenzyme with bound NL1 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-7mcu: Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, Holoenzyme with bound NL2 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-7mcy: Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, Holoenzyme with bound NL3 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-7md0: Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme in the presence of NL1F3 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-7md1: Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103N mutant 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-7md6: Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103N mutant co-crystallized with NL1 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-7md8: Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103N mutant co-crystallized with NL2 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-7md9: Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7mda: Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103A mutant co-crystallized with NL1 手法: X-RAY DIFFRACTION / 解像度: 2.24 Å PDB-7mdb: Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103A mutant co-crystallized with NL2 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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化合物 | ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
ChemComp-IK2: 4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE
ChemComp-LB6: N-[(6-bromo-1H-indol-1-yl)acetyl]glycine
ChemComp-YXA: 5-[(6-bromo-1H-indol-1-yl)methyl]-2-methylfuran-3-carboxylic acid
ChemComp-NL3: 3-{[6-(7-chloro-1-benzothiophen-2-yl)-1H-indol-1-yl]methyl}-1H-pyrazole-5-carboxylic acid
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由来 | - staphylococcus aureus (黄色ブドウ球菌)
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キーワード | LYASE / Amino-acid biosynthesis / Cysteine biosynthesis / Hydrogen sulfide production / PLP dependent enzyme |
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