EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.
ジャーナル・号・ページ	J. Med. Chem., Vol. 64, Page 13902-13917, Year 2021
掲載日	2021年2月11日 (構造データの登録日)
著者	Zahid, H. / Buchholz, C.R. / Singh, M. / Ciccone, M.F. / Chan, A. / Nithianantham, S. / Shi, K. / Aihara, H. / Fischer, M. / Schonbrunn, E. ...Zahid, H. / Buchholz, C.R. / Singh, M. / Ciccone, M.F. / Chan, A. / Nithianantham, S. / Shi, K. / Aihara, H. / Fischer, M. / Schonbrunn, E. / Dos Santos, C.O. / Landry, J.W. / Pomerantz, W.C.K.
リンク	J. Med. Chem. / PubMed:34515477
手法	X線回折
解像度	1.39 - 1.9 Å
構造データ	PDB-7lp0: Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-077 手法: X-RAY DIFFRACTION / 解像度: 1.66 Å PDB-7lpk: Crystal structure of BPTF bromodomain in complex with inhibitor HZ-03-112 手法: X-RAY DIFFRACTION / 解像度: 1.39 Å PDB-7lrk: Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-093 手法: X-RAY DIFFRACTION / 解像度: 1.44 Å PDB-7lro: Crystal structure of BPTF bromodomain in complex with inhibitor HZ-01-105 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-7rwn: Crystal Structure of BPTF bromodomain in complex with 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.39 Å PDB-7rwo: Crystal Structure of BPTF bromodomain in complex with 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å PDB-7rwp: Crystal Structure of BPTF bromodomain in complex with 5-[4-(aminomethyl)anilino]-4-chloro-2-methylpyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-7rwq: Crystal Structure of BPTF bromodomain in complex with 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å
化合物	ChemComp-P2L: 4-chlorol-2-methyl-5-[[(3~{R})-1-methylpiperidin-3-yl]amino]pyridazin-3-one ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-HOH: WATER ChemComp-Y9P: 4-chloranyl-2-methyl-5-[[(3~{R})-pyrrolidin-3-yl]amino]pyridazin-3-one ChemComp-YC4: 4-chloranyl-2-methyl-5-[[(3~{S})-pyrrolidin-3-yl]amino]pyridazin-3-one ChemComp-YBV: 5-(azetidin-3-ylamino)-4-chloranyl-2-methyl-pyridazin-3-one ChemComp-7WE: 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one ChemComp-7WN: 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyridazin-3(2H)-one ChemComp-7WZ: 5-[4-(aminomethyl)anilino]-4-chloro-2-methylpyridazin-3(2H)-one ChemComp-CA: Unknown entry / カルシウムジカチオン ChemComp-7XE*: 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one
由来	homo sapiens (ヒト)
キーワード	GENE REGULATION/INHIBITOR / BPTF / bromodomain / inhibitor / GENE REGULATION / GENE REGULATION-INHIBITOR complex / BRD4