EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Crystal Structure of a human cyclic GMP-AMP synthase complex
ジャーナル・号・ページ	To be published
掲載日	2023年2月8日 (構造データの登録日)
著者	Groebke-Zbinden, K. / Vandemeulebroucke, A. / Hilbert, M. / Rudolph, M.G.
リンク	PubMedで検索
手法	X線回折
解像度	1.444 - 2.831 Å
構造データ	PDB-7ftf: Crystal Structure of apo human cyclic GMP-AMP synthase 手法: X-RAY DIFFRACTION / 解像度: 1.508 Å PDB-7ftg: Crystal Structure of human cyclic GMP-AMP synthase in complex with cGAMP 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-7fth: Crystal Structure of human cyclic GMP-AMP synthase in complex with cGAMP 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-7fti: Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-(4-fluorophenyl)-2-methylpyrazole-3-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-7ftj: Crystal Structure of apo human cyclic GMP-AMP synthase 手法: X-RAY DIFFRACTION / 解像度: 1.461 Å PDB-7ftk: Crystal Structure of apo human cyclic GMP-AMP synthase 手法: X-RAY DIFFRACTION / 解像度: 2.125 Å PDB-7ftl: Crystal Structure of human cyclic GMP-AMP synthase in complex with 8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-7ftm: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[2-(4-fluoroanilino)-1,3-thiazol-4-yl]acetic acid 手法: X-RAY DIFFRACTION / 解像度: 1.698 Å PDB-7ftn: Crystal Structure of human cyclic GMP-AMP synthase in complex with propanedioic acid 手法: X-RAY DIFFRACTION / 解像度: 2.001 Å PDB-7fto: Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-5-fluoro-4-methylphenyl)-1H-benzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-7ftp: Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(4-chlorophenyl)-10,11-dimethoxy-7-methyl-2,4,6-triazatricyclo[7.3.1.05,13]trideca-1(12),2,4,7,9(13),10-hexaene 手法: X-RAY DIFFRACTION / 解像度: 2.48 Å PDB-7ftq: Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-5-fluoro-4-methylphenyl)-1H-benzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.08 Å PDB-7ftr: Crystal Structure of human cyclic GMP-AMP synthase in complex with (Z)-N-(4-acetylphenyl)-2-cyano-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-7fts: Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-bromo-N-[[2-fluoro-5-(1-methylpyrazol-4-yl)phenyl]methyl]-2-hydroxybenzamide 手法: X-RAY DIFFRACTION / 解像度: 2.215 Å PDB-7ftt: Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-bromo-N-[[2-fluoro-5-(1-methylpyrazol-4-yl)phenyl]methyl]-2-hydroxybenzamide 手法: X-RAY DIFFRACTION / 解像度: 2.235 Å PDB-7ftu: Crystal Structure of human cyclic GMP-AMP synthase in complex with (Z)-N-[4-(4-chlorophenyl)sulfonylphenyl]-2-cyano-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-7ftv: Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-bromo-2-hydroxy-N-(quinolin-6-ylmethyl)benzamide 手法: X-RAY DIFFRACTION / 解像度: 1.875 Å PDB-7ftw: Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-bromo-2-hydroxy-N-[[3-(1-methylpyrazol-4-yl)phenyl]methyl]benzamide 手法: X-RAY DIFFRACTION / 解像度: 2.208 Å PDB-7ftx: Crystal Structure of apo human cyclic GMP-AMP synthase - hexagonal form 手法: X-RAY DIFFRACTION / 解像度: 2.831 Å PDB-7fty: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(4-phenylphenyl)methylamino]-5-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one:2,2,2-trifluoroacetic acid 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-7ftz: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[2-[3-[[(5-bromo-2-hydroxybenzoyl)amino]methyl]anilino]-1,3-thiazol-4-yl]acetic acid 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-7fu0: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(4-phenylphenyl)methylamino]-5-(trifluoromethyl)-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 1.969 Å PDB-7fu1: Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-[3-[[(5-bromo-2-hydroxybenzoyl)amino]methyl]phenyl]-2-methylpyrazole-3-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.074 Å PDB-7fu2: Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-5-fluoro-4-methylphenyl)-1H-benzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-7fu3: Crystal Structure of human cyclic GMP-AMP synthase in complex with 8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.822 Å PDB-7fu4: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(2-fluoro-4-phenylphenyl)methylamino]-5-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 1.926 Å PDB-7fu5: Crystal Structure of human cyclic GMP-AMP synthase 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å PDB-7fu6: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-benzyl-6-(2-chloro-4-methylphenyl)indazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.37 Å PDB-7fu7: Crystal Structure of human cyclic GMP-AMP synthase 手法: X-RAY DIFFRACTION / 解像度: 2.24 Å PDB-7fu8: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(2-chloro-5-pyridin-4-ylphenyl)methylamino]-5-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 1.718 Å PDB-7fu9: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(2-chloro-5-pyridin-4-ylphenyl)methylamino]-5-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 1.668 Å PDB-7fua: Crystal Structure of human cyclic GMP-AMP synthase in complex with phosphate 手法: X-RAY DIFFRACTION / 解像度: 1.444 Å PDB-7fub: Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-4-methylphenyl)-3-(pyridin-4-ylmethyl)benzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.981 Å PDB-7fuc: Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-4-methylphenyl)-2-(morpholin-4-ylmethyl)-1H-benzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.52 Å PDB-7fud: Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-benzyl-2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 2.026 Å PDB-7fue: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-5-(2-phenylethyl)-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 2.169 Å PDB-7fuf: Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-benzyl-2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 1.919 Å PDB-7fug: Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-benzyl-2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 2.106 Å PDB-7fuh: Crystal Structure of human cyclic GMP-AMP synthase in complex with phosphate 手法: X-RAY DIFFRACTION / 解像度: 1.944 Å PDB-7fui: Crystal Structure of human cyclic GMP-AMP synthase in complex with (Z)-2-cyano-N-[4-(3-fluorophenyl)-5-methylsulfonylpyrimidin-2-yl]-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-7fuj: Crystal Structure of human cyclic GMP-AMP synthase in complex with (Z)-2-cyano-N-[4-(3-fluorophenyl)-5-methylsulfonylpyrimidin-2-yl]-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-7fuk: Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-4-methylphenyl)-3-(2-phenylethyl)benzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.606 Å PDB-7ful: Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-4-methylphenyl)-3-[3-(methanesulfonamido)propyl]benzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.296 Å PDB-7fum: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(4-benzylpiperazin-1-yl)methyl]-6-(2-chloro-4-methylphenyl)-1H-benzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-7fun: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(4-benzylpiperazin-1-yl)methyl]-6-(2-chloro-4-methylphenyl)-1H-benzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å PDB-7fuo: Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(2-chlorophenyl)methylamino]-5-[(2-fluoroanilino)methyl]-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-7fup: Crystal Structure of human cyclic GMP-AMP synthase in complex with methyl 1-benzoyl-3-methyl-5-(1,2-oxazol-5-yl)pyrazole-4-carboxylate 手法: X-RAY DIFFRACTION / 解像度: 2.411 Å PDB-7fuq: Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-4-methylphenyl)-3-phenylbenzimidazole-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.757 Å PDB-7fur: Crystal Structure of human cyclic GMP-AMP synthase in complex with 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-HOH: WATER ChemComp-1SY: cGAMP / 2′,3′-cGAMP 化合物画像なし ChemComp-YMI: Unknown entry ChemComp-K: Unknown entry / カリウムカチオン化合物画像なし ChemComp-YME: Unknown entry 化合物画像なし ChemComp-YO6: Unknown entry ChemComp-MLI: MALONATE ION / マロナ-ト ChemComp-FMT: FORMIC ACID / ギ酸化合物画像なし ChemComp-YM9: Unknown entry 化合物画像なし ChemComp-YQ8: Unknown entry ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP / ATP, エネルギー貯蔵分子YM ChemComp-SO4: SULFATE ION / 硫酸ジアニオン化合物画像なし ChemComp-YQH: Unknown entry 化合物画像なし ChemComp-YPU: Unknown entry 化合物画像なし ChemComp-YPD: Unknown entry 化合物画像なし ChemComp-YP3: Unknown entry 化合物画像なし ChemComp-YPL: Unknown entry 化合物画像なし ChemComp-YQZ: Unknown entry 化合物画像なし ChemComp-YQQ: Unknown entry 化合物画像なし ChemComp-YTU: Unknown entry 化合物画像なし ChemComp-YU2: Unknown entry 化合物画像なし ChemComp-YMO: Unknown entry 化合物画像なし ChemComp-YMT: Unknown entry 化合物画像なし ChemComp-YNW: Unknown entry 化合物画像なし ChemComp-YOB: Unknown entry 化合物画像なし ChemComp-YQ3: Unknown entry 化合物画像なし ChemComp-YQL: Unknown entry 化合物画像なし ChemComp-YP8: Unknown entry 化合物画像なし ChemComp-YQC: Unknown entry 化合物画像なし ChemComp-YR6: Unknown entry 化合物画像なし ChemComp-YQU: Unknown entry 化合物画像なし ChemComp-YUO: Unknown entry 化合物画像なし ChemComp-YU6: Unknown entry ChemComp-IOD: IODIDE ION / ヨ-ジド ChemComp-CL: Unknown entry / クロリド化合物画像なし ChemComp-YUB: Unknown entry ChemComp-PPI: PROPANOIC ACID / プロピオン酸化合物画像なし ChemComp-YUF: Unknown entry ChemComp-JUJ*: 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one
由来	homo sapiens (ヒト) synthetic construct (人工物)
キーワード	TRANSFERASE / IMMUNE RESPONSE / NTASE / DNA SENSOR / NUCLEOTIDYLTRANSFERASE / CYCLIC GMP-AMP SYNTHASE / CGAS / DNA-BINDING / ACTIVATOR DNA / PATTERN RECOGNITION RECEPTOR / INNATE IMMUNE RESPONSE / VIRAL DNA RECOGNITION / TRANSFERASE/DNA / TRANSFERASE-DNA complex