+検索条件
-Structure paper
タイトル | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants. |
---|---|
ジャーナル・号・ページ | Nat Commun, Vol. 12, Issue 1, Page 6304, Year 2021 |
掲載日 | 2021年11月2日 |
著者 | Tingting Li / Xiaojian Han / Chenjian Gu / Hangtian Guo / Huajun Zhang / Yingming Wang / Chao Hu / Kai Wang / Fengjiang Liu / Feiyang Luo / Yanan Zhang / Jie Hu / Wang Wang / Shenglong Li / Yanan Hao / Meiying Shen / Jingjing Huang / Yingyi Long / Shuyi Song / Ruixin Wu / Song Mu / Qian Chen / Fengxia Gao / Jianwei Wang / Shunhua Long / Luo Li / Yang Wu / Yan Gao / Wei Xu / Xia Cai / Di Qu / Zherui Zhang / Hongqing Zhang / Na Li / Qingzhu Gao / Guiji Zhang / Changlong He / Wei Wang / Xiaoyun Ji / Ni Tang / Zhenghong Yuan / Youhua Xie / Haitao Yang / Bo Zhang / Ailong Huang / Aishun Jin / |
PubMed 要旨 | Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor ...Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor binding domain (RBD) specific monoclonal antibodies (mAbs), 58G6, 510A5 and 13G9, with high neutralizing potency blocking authentic SARS-CoV-2 virus display remarkable efficacy against authentic B.1.351 virus. Surprisingly, structural analysis has revealed that 58G6 and 13G9 both recognize the steric region S on the RBD, overlapping the E484K mutation presented in B.1.351. Also, 58G6 directly binds to another region S in the RBD. Significantly, 58G6 and 510A5 both demonstrate prophylactic efficacy against authentic SARS-CoV-2 and B.1.351 viruses in the transgenic mice expressing human ACE2 (hACE2), protecting weight loss and reducing virus loads. Together, we have evidenced 2 potent neutralizing Abs with unique mechanism targeting authentic SARS-CoV-2 mutants, which can be promising candidates to fulfill the urgent needs for the prolonged COVID-19 pandemic. |
リンク | Nat Commun / PubMed:34728625 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.6 - 3.9 Å |
構造データ | EMDB-30982, PDB-7e3k: EMDB-30983, PDB-7e3l: |
化合物 | ChemComp-NAG: |
由来 |
|
キーワード | VIRAL PROTEIN / COVID-19 / spike glycoprotein / virus / antibody |