EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.
ジャーナル・号・ページ	Eur. J. Med. Chem., Vol. 228, Page 113965-113965, Year 2022
掲載日	2021年1月7日 (構造データの登録日)
著者	Yan, Y.H. / Li, W. / Chen, W. / Li, C. / Zhu, K.R. / Deng, J. / Dai, Q.Q. / Yang, L.L. / Wang, Z. / Li, G.B.
リンク	Eur. J. Med. Chem. / PubMed:34763944
手法	X線回折
解像度	1.599 - 3.227 Å
構造データ	PDB-7du1: Crystal structure of VIM-2 MBL in complex with 1-propyl-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-7dub: Crystal structure of VIM-2 MBL in complex with 1-isopropyl-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.599 Å PDB-7due: Crystal structure of VIM-2 MBL in complex with (R)-1-(sec-butyl)-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.799 Å PDB-7dux: Crystal structure of VIM-2 MBL in complex with 1-(but-3-en-1-yl)-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.981 Å PDB-7duy: Crystal structure of VIM-2 MBL in complex with 1-(2-(1H-1,2,3-triazol-1-yl)ethyl)-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.999 Å PDB-7duz: Crystal structure of VIM-2 MBL in complex with 1-cyclobutyl-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-7dv0: Crystal structure of VIM-2 MBL in complex with 1-(4-(trifluoromethyl)benzyl)-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.601 Å PDB-7dv1: Crystal structure of VIM-2 MBL in complex with 1-(4-hydroxybenzyl)-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.966 Å PDB-7dyy: Crystal structure of VIM-2 MBL in complex with 1-((2-aminobenzo[d]thiazol-6-yl)methyl)-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.798 Å PDB-7dyz: Crystal structure of VIM-2 MBL in complex with 1-(but-3-en-1-yl)-4-methyl-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.902 Å PDB-7dz0: Crystal structure of VIM-2 MBL in complex with 1-(but-3-en-1-yl)-5-methyl-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 3.227 Å PDB-7dz1: Crystal structure of VIM-2 MBL in complex with 1-benzyl-5-methyl-1H-imidazole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.708 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-HKR: 1-propylimidazole-2-carboxylic acid ChemComp-FMT: FORMIC ACID / ギ酸 ChemComp-HOH: WATER ChemComp-HKU: 1-propan-2-ylimidazole-2-carboxylic acid ChemComp-HL3: 1-[(2~{R})-butan-2-yl]imidazole-2-carboxylic acid ChemComp-HLF: 1-but-3-enylimidazole-2-carboxylic acid ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-HLL: 1-[2-(1,2,3-triazol-1-yl)ethyl]imidazole-2-carboxylic acid ChemComp-HM0: 1-cyclobutylimidazole-2-carboxylic acid ChemComp-HML: 1-[[4-(trifluoromethyl)phenyl]methyl]imidazole-2-carboxylic acid ChemComp-HN9: 1-[(4-hydroxyphenyl)methyl]imidazole-2-carboxylic acid / 1-(4-ヒドロキシベンジル)-1H-イミダゾ-ル-2-カルボン酸 ChemComp-HQF: 1-[(2-azanyl-1,3-benzothiazol-6-yl)methyl]imidazole-2-carboxylic acid ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-HQR: 1-but-3-enyl-4-methyl-imidazole-2-carboxylic acid ChemComp-HQ0: 1-but-3-enyl-5-methyl-imidazole-2-carboxylic acid ChemComp-HQ3: 5-methyl-1-(phenylmethyl)imidazole-2-carboxylic acid
由来	pseudomonas aeruginosa (緑膿菌)
キーワード	HYDROLASE / Metallo-beta-lactamase VIM-2 / VIM-2