EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
ジャーナル・号・ページ	Sci Adv, Vol. 7, Year 2021
掲載日	2020年4月28日 (構造データの登録日)
著者	Deluigi, M. / Klipp, A. / Klenk, C. / Merklinger, L. / Eberle, S.A. / Morstein, L. / Heine, P. / Mittl, P.R.E. / Ernst, P. / Kamenecka, T.M. ...Deluigi, M. / Klipp, A. / Klenk, C. / Merklinger, L. / Eberle, S.A. / Morstein, L. / Heine, P. / Mittl, P.R.E. / Ernst, P. / Kamenecka, T.M. / He, Y. / Vacca, S. / Egloff, P. / Honegger, A. / Pluckthun, A.
リンク	Sci Adv / PubMed:33571132
手法	X線回折
解像度	2.458 - 3.192 Å
構造データ	PDB-6yvr: Crystal structure of the neurotensin receptor 1 in complex with the peptide full agonist NTS8-13 手法: X-RAY DIFFRACTION / 解像度: 2.458 Å PDB-6z4q: Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A 手法: X-RAY DIFFRACTION / 解像度: 2.923 Å PDB-6z4s: Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with the small molecule inverse agonist SR48692 手法: X-RAY DIFFRACTION / 解像度: 2.707 Å PDB-6z4v: Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with NTS8-13 手法: X-RAY DIFFRACTION / 解像度: 2.595 Å PDB-6z66: Crystal structure of apo-state neurotensin receptor 1 手法: X-RAY DIFFRACTION / 解像度: 3.192 Å PDB-6z8n: Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist SRI-9829 手法: X-RAY DIFFRACTION / 解像度: 2.803 Å PDB-6za8: Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a 手法: X-RAY DIFFRACTION / 解像度: 2.72 Å PDB-6zin: Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692 手法: X-RAY DIFFRACTION / 解像度: 2.639 Å
化合物	ChemComp-BNG: nonyl beta-D-glucopyranoside / ノニルβ-D-グルコピラノシド / 可溶化剤YM ChemComp-HOH: WATER ChemComp-Q6N: 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid ChemComp-Q6Q: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid ChemComp-SR9: (2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid ChemComp-SR5*: (2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acid
由来	rattus norvegicus (ドブネズミ) synthetic construct (人工物)
キーワード	MEMBRANE PROTEIN / GPCR-ligand complex / NTSR1 / NTS8-13 / full agonist / rNTSR1 / SR142948A / inverse agonist / GPCR ligand complex / SR48692 / GPCR / apo-state / SRI-9829 / RTI-3a / partial agonist