タイトル | Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling |
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ジャーナル・号・ページ | J. Magn. Reson., Year 2021 |
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掲載日 | 2020年6月9日 (構造データの登録日) |
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著者 | Roske, Y. / Heinemann, U. / Oschkinat, H. / Kamdem, N. / Kovalskyy, D. / Platonov, M.O. / Balinskyi, O.M. / Kreuchwig, A. / Saupe, J. / Fang, L. ...Roske, Y. / Heinemann, U. / Oschkinat, H. / Kamdem, N. / Kovalskyy, D. / Platonov, M.O. / Balinskyi, O.M. / Kreuchwig, A. / Saupe, J. / Fang, L. / Diehl, A. / Schmieder, P. / Krause, G. / Rademann, J. / Birchmeier, W. |
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リンク | J. Magn. Reson. / PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.43 - 2.76 Å |
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構造データ | PDB-6zbq: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-6zbz: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6zc3: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling 手法: X-RAY DIFFRACTION / 解像度: 1.67 Å PDB-6zc4: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6zc6: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å PDB-6zc7: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling 手法: X-RAY DIFFRACTION / 解像度: 1.48 Å PDB-6zc8: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling 手法: X-RAY DIFFRACTION / 解像度: 2.76 Å |
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化合物 | ChemComp-QE2: 5-fluoranyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)benzoic acid
ChemComp-QE5: 2-[(3,4-dimethylphenyl)sulfonylamino]-5-fluoranyl-benzoic acid
ChemComp-JOR: 5-fluoranyl-2-(methylsulfonylamino)benzoic acid
ChemComp-QEZ: 5-bromanyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)benzoic acid
ChemComp-QEN: 5-bromanyl-2-(naphthalen-2-ylsulfonylamino)benzoic acid
ChemComp-V31: 5-bromanyl-2-[(phenylmethyl)sulfonylamino]benzoic acid
ChemComp-QEK: 2-[[3-chloranyl-4-[(1~{H}-indazol-3-ylcarbonylamino)methyl]phenyl]sulfonylamino]-5-methyl-benzoic acid
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由来 | homo sapiens (ヒト)
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キーワード | PEPTIDE BINDING PROTEIN / PDZ / DVL / Inhibitors / Wnt / signalling |
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