EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure of the merozoite surface protein 1 from .
ジャーナル・号・ページ	Sci Adv, Vol. 7, Issue 23, Year 2021
掲載日	2021年6月2日
著者	Patricia M Dijkman / Tanja Marzluf / Yingyi Zhang / Shih-Ying Scott Chang / Dominic Helm / Michael Lanzer / Hermann Bujard / Mikhail Kudryashev /
PubMed 要旨	The merozoite surface protein 1 (MSP-1) is the most abundant protein on the surface of the erythrocyte-invading merozoite, the causative agent of malaria. MSP-1 is essential for merozoite formation, ...The merozoite surface protein 1 (MSP-1) is the most abundant protein on the surface of the erythrocyte-invading merozoite, the causative agent of malaria. MSP-1 is essential for merozoite formation, entry into and escape from erythrocytes, and is a promising vaccine candidate. Here, we present monomeric and dimeric structures of full-length MSP-1. MSP-1 adopts an unusual fold with a large central cavity. Its fold includes several coiled-coils and shows structural homology to proteins associated with membrane and cytoskeleton interactions. MSP-1 formed dimers through these domains in a concentration-dependent manner. Dimerization is affected by the presence of the erythrocyte cytoskeleton protein spectrin, which may compete for the dimerization interface. Our work provides structural insights into the possible mode of interaction of MSP-1 with erythrocytes and establishes a framework for future investigations into the role of MSP-1 in infection and immunity.
リンク	Sci Adv / PubMed:34078606 / PubMed Central
手法	EM (単粒子)
解像度	3.1 - 3.6 Å
構造データ	11150 6zbc EMDB-11150, PDB-6zbc: Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, main conformation 手法: EM (単粒子) / 解像度: 3.1 Å 11151 6zbd EMDB-11151, PDB-6zbd: Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 2 手法: EM (単粒子) / 解像度: 3.21 Å 11152 6zbe EMDB-11152, PDB-6zbe: Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 1 手法: EM (単粒子) / 解像度: 3.3 Å 11153 6zbf EMDB-11153, PDB-6zbf: Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 3 手法: EM (単粒子) / 解像度: 3.2 Å 11154 6zbg EMDB-11154, PDB-6zbg: Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 4 手法: EM (単粒子) / 解像度: 3.2 Å 11155 6zbh EMDB-11155, PDB-6zbh: Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 5 手法: EM (単粒子) / 解像度: 3.6 Å 11156 6zbj EMDB-11156, PDB-6zbj: Plasmodium falciparum merozoite surface protein 1 dimer, conformation 1 手法: EM (単粒子) / 解像度: 3.3 Å 11157 6zbl EMDB-11157, PDB-6zbl: Plasmodium falciparum merozoite surface protein 1 dimer, conformation 2 手法: EM (単粒子) / 解像度: 3.6 Å
由来	plasmodium falciparum (マラリア病原虫)
キーワード	MEMBRANE PROTEIN / Merozoite surface protein 1 / malaria / Plasmodium falciparum / MSP-1 / p190 / GPI-anchored membrane protein