タイトル | Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 30, Page 127551-127551, Year 2020 |
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掲載日 | 2020年4月6日 (構造データの登録日) |
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著者 | Gradler, U. / Busch, M. / Leuthner, B. / Raba, M. / Burgdorf, L. / Lehmann, M. / Linde, N. / Esdar, C. |
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リンク | Bioorg. Med. Chem. Lett. / PubMed:32927028 |
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手法 | X線回折 |
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解像度 | 2.43 - 2.89 Å |
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構造データ | PDB-6yky: Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.52 Å PDB-6ylc: Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.43 Å PDB-6yll: Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.89 Å |
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化合物 | ChemComp-OWQ: 3-(4-methoxyphenyl)-~{N}-[(3~{R})-1-pyridin-4-ylpyrrolidin-3-yl]-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine
ChemComp-OXW: 5-fluoranyl-2-[5-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]benzenecarbonitrile
ChemComp-OYB: ~{N}4-[3-(4-methoxyphenyl)-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]cyclohexane-1,4-diamine
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / Mitogen-activated protein kinase 6 / human mitogen activated protein kinase 6 (MAPK6) / ERK3 / inhibitor |
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