タイトル | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. |
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ジャーナル・号・ページ | Sci Rep, Vol. 10, Page 19570-19570, Year 2020 |
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掲載日 | 2020年2月26日 (構造データの登録日) |
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著者 | Azarkan, M. / Maquoi, E. / Delbrassine, F. / Herman, R. / M'Rabet, N. / Calvo Esposito, R. / Charlier, P. / Kerff, F. |
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リンク | Sci Rep / PubMed:33177555 |
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手法 | X線回折 |
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解像度 | 1.257 - 1.85 Å |
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構造データ | PDB-6y6l: Structure the ananain protease from Ananas comosus with a thiomethylated catalytic cysteine 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-6ycb: Structure the ananain protease from Ananas comosus covalently bound to with the E64 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.257 Å PDB-6ycc: Structure the ananain protease from Ananas comosus covalently bound to the E64 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-6ycd: Structure the ananain protease from Ananas comosus covalently bound to the TLCK inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-6yce: Structure the bromelain protease from Ananas comosus with a thiomethylated active cysteine 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6ycf: Structure the bromelain protease from Ananas comosus in complex with the E64 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6ycg: Structure the bromelain protease from Ananas comosus in complex with the TLCK inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å |
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化合物 | ChemComp-E64: N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE
ChemComp-TCK: N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide / TLCK
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由来 | ![](img/tx_plant.gif) ananas comosus (アナナス)
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キーワード | HYDROLASE / cysteine protease / stem bromelain protein |
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