タイトル | The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid. |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 59, Page 20154-20160, Year 2020 |
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掲載日 | 2020年6月18日 (構造データの登録日) |
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著者 | Jovanovic, D. / Tremmel, P. / Pallan, P.S. / Egli, M. / Richert, C. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:32757352 |
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手法 | X線回折 |
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解像度 | 1.45 - 1.88 Å |
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構造データ | PDB-6xhc: Structure of glycinyl 5'-O-adenosine phosphoramidate 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6xhd: Structure of Prolinyl-5'-O-adenosine phosphoramidate 手法: X-RAY DIFFRACTION / 解像度: 1.51 Å PDB-6xhe: Structure of beta-prolinyl 5'-O-adenosine phosphoramidate 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6xhf: Structure of Phenylalanyl-5'-O-adenosine phosphoramidate 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å |
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化合物 | ChemComp-V2G: 2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]amino]ethanoic acid / N-(5′-アデニリル)グリシン
ChemComp-V2P: (2~{S})-1-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]pyrrolidine-2-carboxylic acid
ChemComp-V2J: 5'-O-[(S)-[(3S)-3-carboxypyrrolidin-1-yl](hydroxy)phosphoryl]adenosine
ChemComp-V2S: (2~{S})-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]amino]-3-phenyl-propanoic acid / N-(5′-アデニリル)-L-フェニルアラニン
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由来 | ![](img/tx_mammal.gif) bos taurus (ウシ)
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キーワード | RNA BINDING PROTEIN / RNase A complex / phosphoramidate structure / amino acid release / prodrug |
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