タイトル | Structures of LnmK, a Bifunctional Acyltransferase/Decarboxylase, with Substrate Analogues Reveal the Basis for Selectivity and Stereospecificity. |
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ジャーナル・号・ページ | Biochemistry, Vol. 60, Page 365-372, Year 2021 |
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掲載日 | 2020年5月30日 (構造データの登録日) |
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著者 | Stunkard, L.M. / Kick, B.J. / Lohman, J.R. |
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リンク | Biochemistry / PubMed:33482062 |
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手法 | X線回折 |
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解像度 | 1.42 - 1.77 Å |
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構造データ | PDB-6x7l: LnmK in complex with 2-nitronate-propionyl-CoA 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-6x7m: LnmK in complex with 2-nitronate-propionyl-oxa(dethia)-CoA 手法: X-RAY DIFFRACTION / 解像度: 1.61 Å PDB-6x7n: LnmK in complex with 2-nitronate-propionyl-amino(dethia)-CoA 手法: X-RAY DIFFRACTION / 解像度: 1.42 Å PDB-6x7o: LnmK in complex with 2-sulfonate-propionyl-CoA 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-6x7p: LnmK in complex with 2-sulfonate-propionyl-oxa(dethia)-CoA 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å |
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化合物 | ChemComp-KFV: [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium
ChemComp-KGA: [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium
ChemComp-KGJ: [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylamino]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium
ChemComp-SO5: (2~{R})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid
ChemComp-LCV: (2~{S})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid
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由来 | - streptomyces atroolivaceus (バクテリア)
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キーワード | transferase/transferase inhibitor / transferase / lyase / inhibitor / isostere / transferase-transferase inhibitor complex |
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